Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival

Chou Chin Lan, Yao Kuang Wu, Chih Hsin Lee, Yi Chih Huang, Chun Yao Huang, Ying Huang Tsai, Shiu Feng Huang, Thomas Chang Yao Tsao

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: The sensitivity of cytologic examination of pleural effusions is variable and not predictive of prognosis. Survivin is an inhibitor of apoptosis that may be a novel diagnostic/prognostic marker of cancers. This study aimed to determine the diagnostic and prognostic value of measuring survivin mRNA levels in pleural effusions. Methods: Eighty-eight consecutive pleural effusion samples were examined for both cytology and survivin mRNA level. The accuracy of diagnosis and the correlation between survivin mRNA level and survival in malignant pleural effusion (MPE) were determined. Pleural effusions were divided into three groups: Group I, malignancy-associated (n = 44); Group II, inflammatory (n = 27); and Group III, transudative (n = 17). Results: Survivin mRNA levels in Group I (1.03±0.61, range 0-2.96) were significantly higher than those in Groups II (0.45±0.69, range 0-3.30) and III (0.08±0.22, range 00.71) (P, 0.001). Survivin mRNA level was significantly higher in MPE than in non-MPE. The cut-off value for survivin mRNA levels in pleural effusions was 0.074 for the diagnosis of malignancies, with sensitivity, specificity, and positive and negative predictive values of 96%, 45%, 45% and 96%, respectively. Survivin mRNA level in pleural effusions of cancer patients significantly correlated with poor survival. Conclusions: Survivin mRNA level is significantly higher in MPEs. Over-expression of survivin mRNA correlates with poor prognosis in cancer patients.

Original languageEnglish
Article numberhyp151
Pages (from-to)234-240
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume40
Issue number3
DOIs
Publication statusPublished - Nov 22 2009
Externally publishedYes

Fingerprint

Malignant Pleural Effusion
Pleural Effusion
Messenger RNA
Survival
Neoplasms
Cell Biology
Apoptosis
Sensitivity and Specificity

Keywords

  • Cancer
  • Pleural effusion
  • Prognosis
  • Survivin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Lan, C. C., Wu, Y. K., Lee, C. H., Huang, Y. C., Huang, C. Y., Tsai, Y. H., ... Tsao, T. C. Y. (2009). Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival. Japanese Journal of Clinical Oncology, 40(3), 234-240. [hyp151]. https://doi.org/10.1093/jjco/hyp151

Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival. / Lan, Chou Chin; Wu, Yao Kuang; Lee, Chih Hsin; Huang, Yi Chih; Huang, Chun Yao; Tsai, Ying Huang; Huang, Shiu Feng; Tsao, Thomas Chang Yao.

In: Japanese Journal of Clinical Oncology, Vol. 40, No. 3, hyp151, 22.11.2009, p. 234-240.

Research output: Contribution to journalArticle

Lan, CC, Wu, YK, Lee, CH, Huang, YC, Huang, CY, Tsai, YH, Huang, SF & Tsao, TCY 2009, 'Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival', Japanese Journal of Clinical Oncology, vol. 40, no. 3, hyp151, pp. 234-240. https://doi.org/10.1093/jjco/hyp151
Lan, Chou Chin ; Wu, Yao Kuang ; Lee, Chih Hsin ; Huang, Yi Chih ; Huang, Chun Yao ; Tsai, Ying Huang ; Huang, Shiu Feng ; Tsao, Thomas Chang Yao. / Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival. In: Japanese Journal of Clinical Oncology. 2009 ; Vol. 40, No. 3. pp. 234-240.
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AU - Tsai, Ying Huang

AU - Huang, Shiu Feng

AU - Tsao, Thomas Chang Yao

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N2 - Objective: The sensitivity of cytologic examination of pleural effusions is variable and not predictive of prognosis. Survivin is an inhibitor of apoptosis that may be a novel diagnostic/prognostic marker of cancers. This study aimed to determine the diagnostic and prognostic value of measuring survivin mRNA levels in pleural effusions. Methods: Eighty-eight consecutive pleural effusion samples were examined for both cytology and survivin mRNA level. The accuracy of diagnosis and the correlation between survivin mRNA level and survival in malignant pleural effusion (MPE) were determined. Pleural effusions were divided into three groups: Group I, malignancy-associated (n = 44); Group II, inflammatory (n = 27); and Group III, transudative (n = 17). Results: Survivin mRNA levels in Group I (1.03±0.61, range 0-2.96) were significantly higher than those in Groups II (0.45±0.69, range 0-3.30) and III (0.08±0.22, range 00.71) (P, 0.001). Survivin mRNA level was significantly higher in MPE than in non-MPE. The cut-off value for survivin mRNA levels in pleural effusions was 0.074 for the diagnosis of malignancies, with sensitivity, specificity, and positive and negative predictive values of 96%, 45%, 45% and 96%, respectively. Survivin mRNA level in pleural effusions of cancer patients significantly correlated with poor survival. Conclusions: Survivin mRNA level is significantly higher in MPEs. Over-expression of survivin mRNA correlates with poor prognosis in cancer patients.

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