Increased Subsequent Risk of Coronary Heart Disease in Primary Cesarean Delivery Women

A Population-Based Cohort Study

Ching Wei Chuang, Pei Shan Tsai, Jui An Lin, Nandini Meganathan, Yen Chun Fan, Hui Bih Yuan, Ming Chang Kao, Chun Jen Huang

Research output: Contribution to journalArticle

Abstract

Background: Impacts of delivery modes on the subsequent risk of coronary heart disease (CHD) in pregnant women have not been elucidated. Materials and Methods: Data of women who had undergone cesarean delivery (CD cohort) or vaginal delivery (VD cohort) between January 2000 and December 2012 from Taiwan Health Insurance Database were analyzed. All subjects were tracked until December 31, 2013. For women with multiple deliveries, only the first delivery data were included. Study end point was the diagnosis of new-onset CHD after delivery. Results: In total, 51,765 subjects (CD cohort: n = 17,839; VD cohort: n = 33,926) were included. During 1-14 years of follow-up, the incidence rate of new-onset CHD in the CD cohort was significantly higher than in the VD cohort (1.3% [231/17,839] vs. 0.8% [257/33,926], p < 0.001; effect size: 0.30). Analysis revealed that the subsequent risk of CHD in the CD cohort was significantly higher than in the VD cohort (adjusted hazard ratio [HR] = 1.28, 95% confidence intervals [CI]: 1.06-1.55, p = 0.012). We performed sensitivity tests by excluding subjects who had undergone CD due to nonmedical reasons from the CD cohort. The remaining subjects were named as the ∗CD cohort. Analysis also revealed a higher subsequent risk of CHD in the ∗CD cohort than in the VD cohort (adjusted HR = 1.32, 95% CI: 1.08-1.60, p = 0.006). Conclusions: Women who had undergone primary CD, especially those who had undergone CD due to medical reasons, were associated with an ∼30% higher risk of CHD than those who had undergone VD.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalJournal of Women's Health
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 1 2019

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Coronary Disease
Cohort Studies
Population
Confidence Intervals
Health Insurance
Taiwan
Pregnant Women
Databases
Incidence

Keywords

  • anesthesia
  • Cesarean delivery
  • coronary heart disease
  • vaginal delivery

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Increased Subsequent Risk of Coronary Heart Disease in Primary Cesarean Delivery Women : A Population-Based Cohort Study. / Chuang, Ching Wei; Tsai, Pei Shan; Lin, Jui An; Meganathan, Nandini; Fan, Yen Chun; Yuan, Hui Bih; Kao, Ming Chang; Huang, Chun Jen.

In: Journal of Women's Health, Vol. 28, No. 3, 01.03.2019, p. 323-330.

Research output: Contribution to journalArticle

Chuang, Ching Wei ; Tsai, Pei Shan ; Lin, Jui An ; Meganathan, Nandini ; Fan, Yen Chun ; Yuan, Hui Bih ; Kao, Ming Chang ; Huang, Chun Jen. / Increased Subsequent Risk of Coronary Heart Disease in Primary Cesarean Delivery Women : A Population-Based Cohort Study. In: Journal of Women's Health. 2019 ; Vol. 28, No. 3. pp. 323-330.
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abstract = "Background: Impacts of delivery modes on the subsequent risk of coronary heart disease (CHD) in pregnant women have not been elucidated. Materials and Methods: Data of women who had undergone cesarean delivery (CD cohort) or vaginal delivery (VD cohort) between January 2000 and December 2012 from Taiwan Health Insurance Database were analyzed. All subjects were tracked until December 31, 2013. For women with multiple deliveries, only the first delivery data were included. Study end point was the diagnosis of new-onset CHD after delivery. Results: In total, 51,765 subjects (CD cohort: n = 17,839; VD cohort: n = 33,926) were included. During 1-14 years of follow-up, the incidence rate of new-onset CHD in the CD cohort was significantly higher than in the VD cohort (1.3{\%} [231/17,839] vs. 0.8{\%} [257/33,926], p < 0.001; effect size: 0.30). Analysis revealed that the subsequent risk of CHD in the CD cohort was significantly higher than in the VD cohort (adjusted hazard ratio [HR] = 1.28, 95{\%} confidence intervals [CI]: 1.06-1.55, p = 0.012). We performed sensitivity tests by excluding subjects who had undergone CD due to nonmedical reasons from the CD cohort. The remaining subjects were named as the ∗CD cohort. Analysis also revealed a higher subsequent risk of CHD in the ∗CD cohort than in the VD cohort (adjusted HR = 1.32, 95{\%} CI: 1.08-1.60, p = 0.006). Conclusions: Women who had undergone primary CD, especially those who had undergone CD due to medical reasons, were associated with an ∼30{\%} higher risk of CHD than those who had undergone VD.",
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T1 - Increased Subsequent Risk of Coronary Heart Disease in Primary Cesarean Delivery Women

T2 - A Population-Based Cohort Study

AU - Chuang, Ching Wei

AU - Tsai, Pei Shan

AU - Lin, Jui An

AU - Meganathan, Nandini

AU - Fan, Yen Chun

AU - Yuan, Hui Bih

AU - Kao, Ming Chang

AU - Huang, Chun Jen

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N2 - Background: Impacts of delivery modes on the subsequent risk of coronary heart disease (CHD) in pregnant women have not been elucidated. Materials and Methods: Data of women who had undergone cesarean delivery (CD cohort) or vaginal delivery (VD cohort) between January 2000 and December 2012 from Taiwan Health Insurance Database were analyzed. All subjects were tracked until December 31, 2013. For women with multiple deliveries, only the first delivery data were included. Study end point was the diagnosis of new-onset CHD after delivery. Results: In total, 51,765 subjects (CD cohort: n = 17,839; VD cohort: n = 33,926) were included. During 1-14 years of follow-up, the incidence rate of new-onset CHD in the CD cohort was significantly higher than in the VD cohort (1.3% [231/17,839] vs. 0.8% [257/33,926], p < 0.001; effect size: 0.30). Analysis revealed that the subsequent risk of CHD in the CD cohort was significantly higher than in the VD cohort (adjusted hazard ratio [HR] = 1.28, 95% confidence intervals [CI]: 1.06-1.55, p = 0.012). We performed sensitivity tests by excluding subjects who had undergone CD due to nonmedical reasons from the CD cohort. The remaining subjects were named as the ∗CD cohort. Analysis also revealed a higher subsequent risk of CHD in the ∗CD cohort than in the VD cohort (adjusted HR = 1.32, 95% CI: 1.08-1.60, p = 0.006). Conclusions: Women who had undergone primary CD, especially those who had undergone CD due to medical reasons, were associated with an ∼30% higher risk of CHD than those who had undergone VD.

AB - Background: Impacts of delivery modes on the subsequent risk of coronary heart disease (CHD) in pregnant women have not been elucidated. Materials and Methods: Data of women who had undergone cesarean delivery (CD cohort) or vaginal delivery (VD cohort) between January 2000 and December 2012 from Taiwan Health Insurance Database were analyzed. All subjects were tracked until December 31, 2013. For women with multiple deliveries, only the first delivery data were included. Study end point was the diagnosis of new-onset CHD after delivery. Results: In total, 51,765 subjects (CD cohort: n = 17,839; VD cohort: n = 33,926) were included. During 1-14 years of follow-up, the incidence rate of new-onset CHD in the CD cohort was significantly higher than in the VD cohort (1.3% [231/17,839] vs. 0.8% [257/33,926], p < 0.001; effect size: 0.30). Analysis revealed that the subsequent risk of CHD in the CD cohort was significantly higher than in the VD cohort (adjusted hazard ratio [HR] = 1.28, 95% confidence intervals [CI]: 1.06-1.55, p = 0.012). We performed sensitivity tests by excluding subjects who had undergone CD due to nonmedical reasons from the CD cohort. The remaining subjects were named as the ∗CD cohort. Analysis also revealed a higher subsequent risk of CHD in the ∗CD cohort than in the VD cohort (adjusted HR = 1.32, 95% CI: 1.08-1.60, p = 0.006). Conclusions: Women who had undergone primary CD, especially those who had undergone CD due to medical reasons, were associated with an ∼30% higher risk of CHD than those who had undergone VD.

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