Increased serum osteopontin is a risk factor for osteoporosis in menopausal women

I. C. Chang, T. I. Chiang, K. T. Yeh, H. Lee, Y. W. Cheng

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41 Citations (Scopus)

Abstract

Osteopontin (OPN)-deficient mice are resistant to ovariectomy-induced osteoporosis. Therefore, we hypothesized that women with OPN overexpression may show less resistance to postmenopausal osteoporosis. In this study, we first demonstrated that serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women. Introduction: Animal studies indicate that OPN-deficient mice are resistant to ovariectomy-induced osteoporosis. Methods: From 2004 to 2006, 124 women over the age of 45 were enrolled in a menopausal group, while another 95 women, from 25 to 45 years of age with regular menstruation, were enrolled into a childbearing age group. The serum concentrations of OPN were calculated using the enzyme-link immunosorbent assay method, and bone mineral densities were determined with dual energy X-ray absorptiometry. Results: Serum OPN levels had a significant positive correlation with age (menopausal group, p14.7 ng/ml) was a significant risk factor causing menopausal osteoporosis (odds ratio=2.96, 95% confidence interval, 1.055-8.345). Conclusion: Serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women.

Original languageEnglish
Pages (from-to)1401-1409
Number of pages9
JournalOsteoporosis International
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

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Keywords

  • Bone mineral density
  • Estrogen
  • Osteopontin (OPN)
  • Postmenopausal osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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