Increased serum osteopontin is a risk factor for osteoporosis in menopausal women

I. C. Chang, T. I. Chiang, K. T. Yeh, H. Lee, Y. W. Cheng

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Osteopontin (OPN)-deficient mice are resistant to ovariectomy-induced osteoporosis. Therefore, we hypothesized that women with OPN overexpression may show less resistance to postmenopausal osteoporosis. In this study, we first demonstrated that serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women. Introduction: Animal studies indicate that OPN-deficient mice are resistant to ovariectomy-induced osteoporosis. Methods: From 2004 to 2006, 124 women over the age of 45 were enrolled in a menopausal group, while another 95 women, from 25 to 45 years of age with regular menstruation, were enrolled into a childbearing age group. The serum concentrations of OPN were calculated using the enzyme-link immunosorbent assay method, and bone mineral densities were determined with dual energy X-ray absorptiometry. Results: Serum OPN levels had a significant positive correlation with age (menopausal group, p14.7 ng/ml) was a significant risk factor causing menopausal osteoporosis (odds ratio=2.96, 95% confidence interval, 1.055-8.345). Conclusion: Serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women.

Original languageEnglish
Pages (from-to)1401-1409
Number of pages9
JournalOsteoporosis International
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Fingerprint

Osteopontin
Osteoporosis
Postmenopausal Osteoporosis
Serum
Ovariectomy
Early Diagnosis
Age Groups
Biomarkers
Immunosorbents
Menstruation
Photon Absorptiometry
Bone Density
Odds Ratio
Confidence Intervals
Enzymes

Keywords

  • Bone mineral density
  • Estrogen
  • Osteopontin (OPN)
  • Postmenopausal osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Increased serum osteopontin is a risk factor for osteoporosis in menopausal women. / Chang, I. C.; Chiang, T. I.; Yeh, K. T.; Lee, H.; Cheng, Y. W.

In: Osteoporosis International, Vol. 21, No. 8, 08.2010, p. 1401-1409.

Research output: Contribution to journalArticle

Chang, I. C. ; Chiang, T. I. ; Yeh, K. T. ; Lee, H. ; Cheng, Y. W. / Increased serum osteopontin is a risk factor for osteoporosis in menopausal women. In: Osteoporosis International. 2010 ; Vol. 21, No. 8. pp. 1401-1409.
@article{48119198f09e4e43969583e2745ad6b8,
title = "Increased serum osteopontin is a risk factor for osteoporosis in menopausal women",
abstract = "Osteopontin (OPN)-deficient mice are resistant to ovariectomy-induced osteoporosis. Therefore, we hypothesized that women with OPN overexpression may show less resistance to postmenopausal osteoporosis. In this study, we first demonstrated that serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women. Introduction: Animal studies indicate that OPN-deficient mice are resistant to ovariectomy-induced osteoporosis. Methods: From 2004 to 2006, 124 women over the age of 45 were enrolled in a menopausal group, while another 95 women, from 25 to 45 years of age with regular menstruation, were enrolled into a childbearing age group. The serum concentrations of OPN were calculated using the enzyme-link immunosorbent assay method, and bone mineral densities were determined with dual energy X-ray absorptiometry. Results: Serum OPN levels had a significant positive correlation with age (menopausal group, p14.7 ng/ml) was a significant risk factor causing menopausal osteoporosis (odds ratio=2.96, 95{\%} confidence interval, 1.055-8.345). Conclusion: Serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women.",
keywords = "Bone mineral density, Estrogen, Osteopontin (OPN), Postmenopausal osteoporosis",
author = "Chang, {I. C.} and Chiang, {T. I.} and Yeh, {K. T.} and H. Lee and Cheng, {Y. W.}",
year = "2010",
month = "8",
doi = "10.1007/s00198-009-1107-7",
language = "English",
volume = "21",
pages = "1401--1409",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "8",

}

TY - JOUR

T1 - Increased serum osteopontin is a risk factor for osteoporosis in menopausal women

AU - Chang, I. C.

AU - Chiang, T. I.

AU - Yeh, K. T.

AU - Lee, H.

AU - Cheng, Y. W.

PY - 2010/8

Y1 - 2010/8

N2 - Osteopontin (OPN)-deficient mice are resistant to ovariectomy-induced osteoporosis. Therefore, we hypothesized that women with OPN overexpression may show less resistance to postmenopausal osteoporosis. In this study, we first demonstrated that serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women. Introduction: Animal studies indicate that OPN-deficient mice are resistant to ovariectomy-induced osteoporosis. Methods: From 2004 to 2006, 124 women over the age of 45 were enrolled in a menopausal group, while another 95 women, from 25 to 45 years of age with regular menstruation, were enrolled into a childbearing age group. The serum concentrations of OPN were calculated using the enzyme-link immunosorbent assay method, and bone mineral densities were determined with dual energy X-ray absorptiometry. Results: Serum OPN levels had a significant positive correlation with age (menopausal group, p14.7 ng/ml) was a significant risk factor causing menopausal osteoporosis (odds ratio=2.96, 95% confidence interval, 1.055-8.345). Conclusion: Serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women.

AB - Osteopontin (OPN)-deficient mice are resistant to ovariectomy-induced osteoporosis. Therefore, we hypothesized that women with OPN overexpression may show less resistance to postmenopausal osteoporosis. In this study, we first demonstrated that serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women. Introduction: Animal studies indicate that OPN-deficient mice are resistant to ovariectomy-induced osteoporosis. Methods: From 2004 to 2006, 124 women over the age of 45 were enrolled in a menopausal group, while another 95 women, from 25 to 45 years of age with regular menstruation, were enrolled into a childbearing age group. The serum concentrations of OPN were calculated using the enzyme-link immunosorbent assay method, and bone mineral densities were determined with dual energy X-ray absorptiometry. Results: Serum OPN levels had a significant positive correlation with age (menopausal group, p14.7 ng/ml) was a significant risk factor causing menopausal osteoporosis (odds ratio=2.96, 95% confidence interval, 1.055-8.345). Conclusion: Serum OPN levels could be used as a biomarker for the early diagnosis of osteoporosis in postmenopausal women.

KW - Bone mineral density

KW - Estrogen

KW - Osteopontin (OPN)

KW - Postmenopausal osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=77954531706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954531706&partnerID=8YFLogxK

U2 - 10.1007/s00198-009-1107-7

DO - 10.1007/s00198-009-1107-7

M3 - Article

C2 - 20238102

AN - SCOPUS:77954531706

VL - 21

SP - 1401

EP - 1409

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 8

ER -