Increased risk of trigeminal neuralgia after hypertension: A population-based study

S. L. Pan, M. F. Yen, Y. H. Chiu, L. S. Chen, H. H. Chen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: Very few studies have explored the temporal relationship between hypertension and trigeminal neuralgia (TN). The aim of this population-based follow-up study was to investigate whether hypertension is associated with a higher risk of developing TN. Methods: A total of 138,492 persons with at least 2 ambulatory visits with the principal diagnosis of hypertension in 2001 were enrolled in the hypertension group. The nonhypertension group consisted of 276,984 age- and sex-matched, randomly sampled subjects without hypertension. The 3-year TN-free survival rate and the cumulative incidence of TN were calculated using the Kaplan-Meier method. Cox proportional hazard regression was used to estimate the hazard ratio of TN. Results: In the hypertension group, 121 patients developed TN during follow-up, while, in the nonhypertension group, 167 subjects developed TN. The crude hazard ratio for the hypertension group was 1.52 (95% confidence interval [CI] 1.20-1.92; p = 0.0005), while, after adjustment for demographic characteristics and medical comorbidities, the adjusted hazard ratio was 1.51 (95% CI 1.19-1.90; p = 0.0006). Conclusions: This study shows a significantly increased risk of developing TN after hypertension. Further studies are needed to elucidate the underlying mechanism of the association between hypertension and TN.

Original languageEnglish
Pages (from-to)1605-1610
Number of pages6
JournalNeurology
Volume77
Issue number17
DOIs
Publication statusPublished - Oct 25 2011

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Fingerprint Dive into the research topics of 'Increased risk of trigeminal neuralgia after hypertension: A population-based study'. Together they form a unique fingerprint.

  • Cite this