Increased risk of stroke after septicaemia: A population-based longitudinal study in Taiwan

Jiunn Tay Lee, Wen Ting Chung, Jin Ding Lin, Giia Sheun Peng, Chih Hsin Muo, Che Chen Lin, Chi Pang Wen, I. Kuan Wang, Chun Hung Tseng, Chia Hung Kao, Chung Y. Hsu

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Inflammation and infection have been noted to increase stroke risk. However, the association between septicaemia and increased risk of stroke remains unclear. This population-based cohort study, using a National Health Insurance database, aimed to investigate whether patients with septicaemia are predisposed to increased stroke risk. The study included all patients hospitalised for septicaemia for the first time between 2000 and 2003 without prior stroke. Patients were followed until the end of 2010 to evaluate incidence of stroke. An age-, gender- and co-morbidities-matched cohort without prior stroke served as the control. Cox's proportional hazards regressions were used to assess differences in stroke risk between groups. Based on hazard ratios (HRs), patients with septicaemia had greater stroke risk, especially in the younger age groups (age 0.05). Haemorrhagic stroke was the dominant type (ischaemic stroke: HR = 1.20, 95% CI: 1.06-1.37, p

Original languageEnglish
Article numbere89386
JournalPLoS One
Issue number2
Publication statusPublished - Feb 21 2014
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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