Abstract

Background: Although studies have indicated that hyperthyroidism is associated with hypercoagulability, most such studies have focused only on examining the incidence of venous thrombosis. As far as we know, no study has attempted to explore the risk of pulmonary embolism (PE) among patients with hyperthyroidism. Objective: Using a nationwide population-based dataset, this study was aimed at estimating the risk of PE among hyperthyroidism patients during a 5-year period, as compared with non-hyperthyroidism patients during the same period. Methods: Data sourced from the Taiwan Longitudinal Health Insurance Database were analyzed. The study included 8903 patients with hyperthyroidism as a study cohort and 44 515 randomly selected patients without hyperthyroidism as a comparison cohort. Stratified Cox proportional hazard regressions were used to compute the 5-year PE-free survival rate between these two cohorts. Results: Of the total of 53 418 patients, 41 patients (0.08%) were identified ashavingPEduring the follow-up period, 14 from the study cohort (0.16% of the hyperthyroidism patients) and 27 comparison patients (0.06% of patients from the comparison cohort). After adjustment for geographic region, monthly income, hypertension, diabetes, hyperlipidemia, peripheral vascular disease, coronary heart disease, cancer, recent surgery, recent fracture, pregnancy and the use of anticoagulants, the risk of havingPEduring the 5-year follow-up period was 2.31 times greater (95% confidence interval 1.20-4.45, P = 0.012) for patients with hyperthyroidism than for patients in the comparison cohort. Conclusion: We found an increased risk of PE in patients with hyperthyroidism. Clinicians should be aware of this increased risk.

Original languageEnglish
Pages (from-to)2176-2181
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Hyperthyroidism
Pulmonary Embolism
Cohort Studies
Heart Neoplasms
Thrombophilia
Peripheral Vascular Diseases
Health Insurance
Hyperlipidemias
Taiwan
Venous Thrombosis
Anticoagulants
Coronary Disease
Survival Rate
Databases
Confidence Intervals

Keywords

  • Epidemiology
  • Hyperthyroidism
  • Pulmonary embolism

ASJC Scopus subject areas

  • Hematology

Cite this

Increased risk of pulmonary embolism among patients with hyperthyroidism : A 5-year follow-up study. / Lin, H. C.; Yang, L. Y.; Kang, J. H.

In: Journal of Thrombosis and Haemostasis, Vol. 8, No. 10, 10.2010, p. 2176-2181.

Research output: Contribution to journalArticle

@article{5cc34bcf29ea4b688b7e7b80c7e7be2c,
title = "Increased risk of pulmonary embolism among patients with hyperthyroidism: A 5-year follow-up study",
abstract = "Background: Although studies have indicated that hyperthyroidism is associated with hypercoagulability, most such studies have focused only on examining the incidence of venous thrombosis. As far as we know, no study has attempted to explore the risk of pulmonary embolism (PE) among patients with hyperthyroidism. Objective: Using a nationwide population-based dataset, this study was aimed at estimating the risk of PE among hyperthyroidism patients during a 5-year period, as compared with non-hyperthyroidism patients during the same period. Methods: Data sourced from the Taiwan Longitudinal Health Insurance Database were analyzed. The study included 8903 patients with hyperthyroidism as a study cohort and 44 515 randomly selected patients without hyperthyroidism as a comparison cohort. Stratified Cox proportional hazard regressions were used to compute the 5-year PE-free survival rate between these two cohorts. Results: Of the total of 53 418 patients, 41 patients (0.08{\%}) were identified ashavingPEduring the follow-up period, 14 from the study cohort (0.16{\%} of the hyperthyroidism patients) and 27 comparison patients (0.06{\%} of patients from the comparison cohort). After adjustment for geographic region, monthly income, hypertension, diabetes, hyperlipidemia, peripheral vascular disease, coronary heart disease, cancer, recent surgery, recent fracture, pregnancy and the use of anticoagulants, the risk of havingPEduring the 5-year follow-up period was 2.31 times greater (95{\%} confidence interval 1.20-4.45, P = 0.012) for patients with hyperthyroidism than for patients in the comparison cohort. Conclusion: We found an increased risk of PE in patients with hyperthyroidism. Clinicians should be aware of this increased risk.",
keywords = "Epidemiology, Hyperthyroidism, Pulmonary embolism",
author = "Lin, {H. C.} and Yang, {L. Y.} and Kang, {J. H.}",
year = "2010",
month = "10",
doi = "10.1111/j.1538-7836.2010.03993.x",
language = "English",
volume = "8",
pages = "2176--2181",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Increased risk of pulmonary embolism among patients with hyperthyroidism

T2 - A 5-year follow-up study

AU - Lin, H. C.

AU - Yang, L. Y.

AU - Kang, J. H.

PY - 2010/10

Y1 - 2010/10

N2 - Background: Although studies have indicated that hyperthyroidism is associated with hypercoagulability, most such studies have focused only on examining the incidence of venous thrombosis. As far as we know, no study has attempted to explore the risk of pulmonary embolism (PE) among patients with hyperthyroidism. Objective: Using a nationwide population-based dataset, this study was aimed at estimating the risk of PE among hyperthyroidism patients during a 5-year period, as compared with non-hyperthyroidism patients during the same period. Methods: Data sourced from the Taiwan Longitudinal Health Insurance Database were analyzed. The study included 8903 patients with hyperthyroidism as a study cohort and 44 515 randomly selected patients without hyperthyroidism as a comparison cohort. Stratified Cox proportional hazard regressions were used to compute the 5-year PE-free survival rate between these two cohorts. Results: Of the total of 53 418 patients, 41 patients (0.08%) were identified ashavingPEduring the follow-up period, 14 from the study cohort (0.16% of the hyperthyroidism patients) and 27 comparison patients (0.06% of patients from the comparison cohort). After adjustment for geographic region, monthly income, hypertension, diabetes, hyperlipidemia, peripheral vascular disease, coronary heart disease, cancer, recent surgery, recent fracture, pregnancy and the use of anticoagulants, the risk of havingPEduring the 5-year follow-up period was 2.31 times greater (95% confidence interval 1.20-4.45, P = 0.012) for patients with hyperthyroidism than for patients in the comparison cohort. Conclusion: We found an increased risk of PE in patients with hyperthyroidism. Clinicians should be aware of this increased risk.

AB - Background: Although studies have indicated that hyperthyroidism is associated with hypercoagulability, most such studies have focused only on examining the incidence of venous thrombosis. As far as we know, no study has attempted to explore the risk of pulmonary embolism (PE) among patients with hyperthyroidism. Objective: Using a nationwide population-based dataset, this study was aimed at estimating the risk of PE among hyperthyroidism patients during a 5-year period, as compared with non-hyperthyroidism patients during the same period. Methods: Data sourced from the Taiwan Longitudinal Health Insurance Database were analyzed. The study included 8903 patients with hyperthyroidism as a study cohort and 44 515 randomly selected patients without hyperthyroidism as a comparison cohort. Stratified Cox proportional hazard regressions were used to compute the 5-year PE-free survival rate between these two cohorts. Results: Of the total of 53 418 patients, 41 patients (0.08%) were identified ashavingPEduring the follow-up period, 14 from the study cohort (0.16% of the hyperthyroidism patients) and 27 comparison patients (0.06% of patients from the comparison cohort). After adjustment for geographic region, monthly income, hypertension, diabetes, hyperlipidemia, peripheral vascular disease, coronary heart disease, cancer, recent surgery, recent fracture, pregnancy and the use of anticoagulants, the risk of havingPEduring the 5-year follow-up period was 2.31 times greater (95% confidence interval 1.20-4.45, P = 0.012) for patients with hyperthyroidism than for patients in the comparison cohort. Conclusion: We found an increased risk of PE in patients with hyperthyroidism. Clinicians should be aware of this increased risk.

KW - Epidemiology

KW - Hyperthyroidism

KW - Pulmonary embolism

UR - http://www.scopus.com/inward/record.url?scp=78649352748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649352748&partnerID=8YFLogxK

U2 - 10.1111/j.1538-7836.2010.03993.x

DO - 10.1111/j.1538-7836.2010.03993.x

M3 - Article

C2 - 20738759

AN - SCOPUS:78649352748

VL - 8

SP - 2176

EP - 2181

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 10

ER -