Increased risk of preterm births among women with uterine leiomyoma: A nationwide population-based study

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

BACKGROUND: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma. METHODS: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers. RESULTS: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78, P <0.001) and SGA infants (19.00 versus 17.28, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P <0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95 CI 1.19-1.46) and 1.16 (95 CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022). CONCLUSIONS: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy.

Original languageEnglish
Pages (from-to)3049-3056
Number of pages8
JournalHuman Reproduction
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Premature Birth
Leiomyoma
Mothers
Population
Small for Gestational Age Infant
Gestational Age
Multivariate Analysis
Regression Analysis
Birth Certificates
Pregnancy
National Health Programs
Pregnancy Outcome
Taiwan
Registries
Pregnant Women
Odds Ratio
Databases

Keywords

  • Birthweight
  • Pregnancy
  • Preterm birth
  • Small for gestational age
  • Uterine leiomyoma

ASJC Scopus subject areas

  • Rehabilitation
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Increased risk of preterm births among women with uterine leiomyoma : A nationwide population-based study. / Chen, Yi Hua; Lin, Herng Ching; Chen, Shu Fen; Lin, Hsiu Chen.

In: Human Reproduction, Vol. 24, No. 12, 12.2009, p. 3049-3056.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma. METHODS: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers. RESULTS: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78, P <0.001) and SGA infants (19.00 versus 17.28, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P <0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95 CI 1.19-1.46) and 1.16 (95 CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022). CONCLUSIONS: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy.",
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