Increased Risk of Preterm Birth among Women with Mitral Valve Prolapse: A Nationwide, Population-Based Study

Chao Hung Chen, Ming Chao Huang, Hung Chang Liu, Chang Jer Huang, Herng Ching Lin, Yu Ru Kou

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Using nationwide population-based databases, we aimed to assess the association between mitral valve prolapse (MVP) and adverse pregnancy outcomes. Methods: The Taiwan Birth Registry and the National Health Insurance Research Dataset were used for analysis. Of all pregnant women in Taiwan who had singleton births in 2005, we identified a total of 3104 mothers diagnosed with MVP during ambulatory or emergency care visits, together with 12,245 mothers unaffected by MPV. Multivariate logistic regression was performed. Results: Multivariate logistic regressions showed that, compared with unaffected mothers, the adjusted odds ratios of preterm birth and cesarean section for mothers with MVP were 1.27 (95% confidence interval [CI], 1.10-1.48) and 1.34 (95% CI, 1.20-1.50), respectively. In further stratification based on the timing of the MVP diagnosis, the highest risks of preterm birth were observed for mothers diagnosed with MVP during (but not before) pregnancy (odds ratio [OR], 1.54; p = .001). No significant difference was observed between women with and without MVP for other outcomes such as low birthweight, intrapartum complications, low Apgar scores, and congenital malformations. Conclusions: Our study found a significant risk of preterm delivery among women with MVP. A multidisciplinary team approach to providing obstetric care, with the mission of monitoring signs of cardiac complications and preterm birth, is imperative.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalAnnals of Epidemiology
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Fingerprint

Mitral Valve Prolapse
Premature Birth
Mothers
Population
Taiwan
Logistic Models
Odds Ratio
Parturition
Confidence Intervals
Apgar Score
National Health Programs
Emergency Medical Services
Pregnancy Outcome
Ambulatory Care
Cesarean Section
Obstetrics
Registries
Pregnant Women
Databases
Pregnancy

Keywords

  • Mitral Valve Prolapse
  • Pregnancy Outcomes
  • Preterm Birth

ASJC Scopus subject areas

  • Epidemiology

Cite this

Increased Risk of Preterm Birth among Women with Mitral Valve Prolapse : A Nationwide, Population-Based Study. / Chen, Chao Hung; Huang, Ming Chao; Liu, Hung Chang; Huang, Chang Jer; Lin, Herng Ching; Kou, Yu Ru.

In: Annals of Epidemiology, Vol. 21, No. 6, 06.2011, p. 391-398.

Research output: Contribution to journalArticle

Chen, Chao Hung ; Huang, Ming Chao ; Liu, Hung Chang ; Huang, Chang Jer ; Lin, Herng Ching ; Kou, Yu Ru. / Increased Risk of Preterm Birth among Women with Mitral Valve Prolapse : A Nationwide, Population-Based Study. In: Annals of Epidemiology. 2011 ; Vol. 21, No. 6. pp. 391-398.
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