Abstract
Background: Periodontitis is a frequently cited extraintestinal manifestation of Crohn’s disease (CD). Despite a plethora of investigations and a recent meta-analysis linking CD and periodontitis, no study has estimated the risk of periodontitis among CD patients with respect to a comparison group nor has any investigation analyzed the effect of CD-specific medications on the risk of periodontitis. The present cohort study compared CD patients and matched subjects without a history of inflammatory bowel disease (IBD) to estimate the effect of CD and CD-specific pharmaceutical prescriptions on the risk of developing periodontitis by leveraging a population-based dataset in Taiwan. Methods: We sourced 6657 CD patients and 26,628 comparison subjects without a history of IBD from the Taiwan National Health Insurance Database. Cox proportional hazards regressions were used to estimate the risk of subsequent periodontitis by CD status and pharmaceutical prescription during the follow-up period. Results: After adjusting for socioeconomic status (SES), urbanicity, selected medical co-morbidities, and CD-specific pharmaceutical prescriptions, the hazard ratio (HR) for subsequent periodontitis among patients with CD was 1.36 (95% CI = 1.25–1.48) that of comparison subjects. There was not a significant difference in risk between genders or across ages. Steroids (95% CI = 0.66–0.77) appeared to confer a protective effect and Aspirin, Plavix, and Licodin were marginally protective (95% CI = 0.76–0.95). Conclusion: This is the first study to report an increased HR for subsequent periodontitis among CD patients when compared to matched comparison subjects without IBD. The protective effect of some pharmaceuticals may suggest that treatment of CD protects against periodontitis.
| Original language | English |
|---|---|
| Pages (from-to) | 1437-1444 |
| Number of pages | 8 |
| Journal | International Journal of Colorectal Disease |
| Volume | 33 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2018 |
Fingerprint
Keywords
- Crohn’s disease
- Epidemiology
- Periodontitis
ASJC Scopus subject areas
- Gastroenterology
Cite this
Increased risk of periodontitis among patients with Crohn’s disease : a population-based matched-cohort study. / Chi, Ying Chen; Chen, Jiunn Liang; Wang, Li Hsuan; Chang, Koyin; Wu, Chen Long; Lin, Shu Yi; Keller, Joseph Jordan; Bai, Chyi Huey.
In: International Journal of Colorectal Disease, Vol. 33, No. 10, 01.10.2018, p. 1437-1444.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased risk of periodontitis among patients with Crohn’s disease
T2 - a population-based matched-cohort study
AU - Chi, Ying Chen
AU - Chen, Jiunn Liang
AU - Wang, Li Hsuan
AU - Chang, Koyin
AU - Wu, Chen Long
AU - Lin, Shu Yi
AU - Keller, Joseph Jordan
AU - Bai, Chyi Huey
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Background: Periodontitis is a frequently cited extraintestinal manifestation of Crohn’s disease (CD). Despite a plethora of investigations and a recent meta-analysis linking CD and periodontitis, no study has estimated the risk of periodontitis among CD patients with respect to a comparison group nor has any investigation analyzed the effect of CD-specific medications on the risk of periodontitis. The present cohort study compared CD patients and matched subjects without a history of inflammatory bowel disease (IBD) to estimate the effect of CD and CD-specific pharmaceutical prescriptions on the risk of developing periodontitis by leveraging a population-based dataset in Taiwan. Methods: We sourced 6657 CD patients and 26,628 comparison subjects without a history of IBD from the Taiwan National Health Insurance Database. Cox proportional hazards regressions were used to estimate the risk of subsequent periodontitis by CD status and pharmaceutical prescription during the follow-up period. Results: After adjusting for socioeconomic status (SES), urbanicity, selected medical co-morbidities, and CD-specific pharmaceutical prescriptions, the hazard ratio (HR) for subsequent periodontitis among patients with CD was 1.36 (95% CI = 1.25–1.48) that of comparison subjects. There was not a significant difference in risk between genders or across ages. Steroids (95% CI = 0.66–0.77) appeared to confer a protective effect and Aspirin, Plavix, and Licodin were marginally protective (95% CI = 0.76–0.95). Conclusion: This is the first study to report an increased HR for subsequent periodontitis among CD patients when compared to matched comparison subjects without IBD. The protective effect of some pharmaceuticals may suggest that treatment of CD protects against periodontitis.
AB - Background: Periodontitis is a frequently cited extraintestinal manifestation of Crohn’s disease (CD). Despite a plethora of investigations and a recent meta-analysis linking CD and periodontitis, no study has estimated the risk of periodontitis among CD patients with respect to a comparison group nor has any investigation analyzed the effect of CD-specific medications on the risk of periodontitis. The present cohort study compared CD patients and matched subjects without a history of inflammatory bowel disease (IBD) to estimate the effect of CD and CD-specific pharmaceutical prescriptions on the risk of developing periodontitis by leveraging a population-based dataset in Taiwan. Methods: We sourced 6657 CD patients and 26,628 comparison subjects without a history of IBD from the Taiwan National Health Insurance Database. Cox proportional hazards regressions were used to estimate the risk of subsequent periodontitis by CD status and pharmaceutical prescription during the follow-up period. Results: After adjusting for socioeconomic status (SES), urbanicity, selected medical co-morbidities, and CD-specific pharmaceutical prescriptions, the hazard ratio (HR) for subsequent periodontitis among patients with CD was 1.36 (95% CI = 1.25–1.48) that of comparison subjects. There was not a significant difference in risk between genders or across ages. Steroids (95% CI = 0.66–0.77) appeared to confer a protective effect and Aspirin, Plavix, and Licodin were marginally protective (95% CI = 0.76–0.95). Conclusion: This is the first study to report an increased HR for subsequent periodontitis among CD patients when compared to matched comparison subjects without IBD. The protective effect of some pharmaceuticals may suggest that treatment of CD protects against periodontitis.
KW - Crohn’s disease
KW - Epidemiology
KW - Periodontitis
UR - http://www.scopus.com/inward/record.url?scp=85049770973&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049770973&partnerID=8YFLogxK
U2 - 10.1007/s00384-018-3117-4
DO - 10.1007/s00384-018-3117-4
M3 - Article
AN - SCOPUS:85049770973
VL - 33
SP - 1437
EP - 1444
JO - International Journal of Colorectal Disease
JF - International Journal of Colorectal Disease
SN - 0179-1958
IS - 10
ER -