10 Citations (Scopus)

Abstract

Background/Aims: Previous studies have suggested that hepatic (toxic-metabolic) encephalopathy, the major complication of cirrhosis, is a neuropsychiatric disorder typically seen in patients with liver dysfunction after exclusion of other known brain disease. This study aims to investigate the risk for parkinsonism during a 7-year follow-up period after a diagnosis of cirrhosis. Methods: In total, 1361 patients with cirrhosis and 6805 comparison patients without cirrhosis were included in this study. Each patient was then individually tracked for 7 years from the time of their initial diagnosis of cirrhosis to identify those who developed parkinsonism during the follow-up period. Stratified Cox proportional hazard regressions were conducted to calculate the hazard of parkinsonism for the two groups during the follow-up period, after adjusting for patient's age, monthly income, level of urbanization and geographic location. Results: Of the total 8166 sampled patients, 141 (1.7%) developed parkinsonism during the follow-up period, 48 from the study group (3.5% of the patients with cirrhosis) and 93 from the comparison group (1.4% of patients in the comparison group). Stratified Cox proportional hazard regressions show that the hazard for parkinsonism for patients with cirrhosis was 2.65 times as high (95% confidence interval=1.85-3.80, P

Original languageEnglish
Pages (from-to)685-691
Number of pages7
JournalLiver International
Volume31
Issue number5
DOIs
Publication statusPublished - May 2011

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Parkinsonian Disorders
Fibrosis
Neurotoxicity Syndromes
Metabolic Brain Diseases
Geographic Locations
Urbanization
Brain Diseases
Liver Diseases
Confidence Intervals
Liver

Keywords

  • Cirrhosis
  • Epidemiology
  • Parkinsonism

ASJC Scopus subject areas

  • Hepatology

Cite this

Increased risk of parkinsonism among patients with cirrhosis : A 7-year follow-up study. / Kang, Jiunn Horng; Tsai, Ming Chieh; Lin, Ching Chun; Lin, Hsiu Li; Lin, Herng Ching.

In: Liver International, Vol. 31, No. 5, 05.2011, p. 685-691.

Research output: Contribution to journalArticle

Kang, Jiunn Horng ; Tsai, Ming Chieh ; Lin, Ching Chun ; Lin, Hsiu Li ; Lin, Herng Ching. / Increased risk of parkinsonism among patients with cirrhosis : A 7-year follow-up study. In: Liver International. 2011 ; Vol. 31, No. 5. pp. 685-691.
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abstract = "Background/Aims: Previous studies have suggested that hepatic (toxic-metabolic) encephalopathy, the major complication of cirrhosis, is a neuropsychiatric disorder typically seen in patients with liver dysfunction after exclusion of other known brain disease. This study aims to investigate the risk for parkinsonism during a 7-year follow-up period after a diagnosis of cirrhosis. Methods: In total, 1361 patients with cirrhosis and 6805 comparison patients without cirrhosis were included in this study. Each patient was then individually tracked for 7 years from the time of their initial diagnosis of cirrhosis to identify those who developed parkinsonism during the follow-up period. Stratified Cox proportional hazard regressions were conducted to calculate the hazard of parkinsonism for the two groups during the follow-up period, after adjusting for patient's age, monthly income, level of urbanization and geographic location. Results: Of the total 8166 sampled patients, 141 (1.7{\%}) developed parkinsonism during the follow-up period, 48 from the study group (3.5{\%} of the patients with cirrhosis) and 93 from the comparison group (1.4{\%} of patients in the comparison group). Stratified Cox proportional hazard regressions show that the hazard for parkinsonism for patients with cirrhosis was 2.65 times as high (95{\%} confidence interval=1.85-3.80, P",
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