Increased risk of osteoporotic fractures in patients with systemic sclerosis: A nationwide population-based study

Chien Chih Lai, Shu Hung Wang, Wei Sheng Chen, Chia Jen Liu, Tzeng Ji Chen, Pui Ching Lee, Yu Sheng Chang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: To identify the incidence rate (IR) and risk factors of osteoporotic fractures (OFs) among systemic sclerosis (SSc) patients. Methods: A cohort study was conducted using the Taiwan National Health Insurance database. Patients with SSc and respective age- and gender-matched controls without SSc were enrolled. The primary endpoint was the first occurrence of OF. The Cox proportional hazard model was used to investigate the risk factor of OFs in the SSc cohort. Results: Among 1712 SSc patients (77.8% female, mean age 50.3 years) with a median follow-up of 5.2 years, 54 patients developed vertebral fractures, 17 patients developed hip fractures, and 7 patients developed radius fractures (IR: 6.99, 2.18 and 0.90 per 1000 person-years, respectively). Compared with the controls, the incidence rate ratios (IRRs) (95% CIs) among SSc patients were 1.78 (1.30 to 2.39, p7.5 mg, and bowel dysmotility treated with intravenous metoclopramide are associated with OF. Conclusions: SSc patients had a high IR of vertebral and hip fractures, especially those who were female, older, used a high dose of corticosteroid or experienced bowel dysmotility.

Original languageEnglish
Pages (from-to)1347-1352
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume74
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

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Osteoporotic Fractures
Systemic Scleroderma
Population
Incidence
Hip Fractures
Health insurance
Radius Fractures
Metoclopramide
National Health Programs
Taiwan
Proportional Hazards Models
Hazards
Adrenal Cortex Hormones
Cohort Studies
Databases

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy
  • Medicine(all)

Cite this

Increased risk of osteoporotic fractures in patients with systemic sclerosis : A nationwide population-based study. / Lai, Chien Chih; Wang, Shu Hung; Chen, Wei Sheng; Liu, Chia Jen; Chen, Tzeng Ji; Lee, Pui Ching; Chang, Yu Sheng.

In: Annals of the Rheumatic Diseases, Vol. 74, No. 7, 01.07.2015, p. 1347-1352.

Research output: Contribution to journalArticle

Lai, Chien Chih ; Wang, Shu Hung ; Chen, Wei Sheng ; Liu, Chia Jen ; Chen, Tzeng Ji ; Lee, Pui Ching ; Chang, Yu Sheng. / Increased risk of osteoporotic fractures in patients with systemic sclerosis : A nationwide population-based study. In: Annals of the Rheumatic Diseases. 2015 ; Vol. 74, No. 7. pp. 1347-1352.
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abstract = "Objectives: To identify the incidence rate (IR) and risk factors of osteoporotic fractures (OFs) among systemic sclerosis (SSc) patients. Methods: A cohort study was conducted using the Taiwan National Health Insurance database. Patients with SSc and respective age- and gender-matched controls without SSc were enrolled. The primary endpoint was the first occurrence of OF. The Cox proportional hazard model was used to investigate the risk factor of OFs in the SSc cohort. Results: Among 1712 SSc patients (77.8{\%} female, mean age 50.3 years) with a median follow-up of 5.2 years, 54 patients developed vertebral fractures, 17 patients developed hip fractures, and 7 patients developed radius fractures (IR: 6.99, 2.18 and 0.90 per 1000 person-years, respectively). Compared with the controls, the incidence rate ratios (IRRs) (95{\%} CIs) among SSc patients were 1.78 (1.30 to 2.39, p7.5 mg, and bowel dysmotility treated with intravenous metoclopramide are associated with OF. Conclusions: SSc patients had a high IR of vertebral and hip fractures, especially those who were female, older, used a high dose of corticosteroid or experienced bowel dysmotility.",
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