Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study

Chung Hsing Chou, Jiunn Tay Lee, Chia Kuang Tsai, Li Ming Lien, Jiu Haw Yin, Chun Chieh Lin, I. Ju Tsai, Yueh Feng Sung, Fu Chi Yang, Chia Lin Tsai, I. Kuan Wang, Chun Hung Tseng, Chung Y. Hsu

Research output: Contribution to journalArticle

Abstract

Background Growing evidence shows links between septicaemia and non-multiple sclerosis demyelinating syndromes (NMSDS); nevertheless, epidemiological data are still very limited. This study aimed to explore the relationship between septicaemia and NMSDS in a general population. Methods The study included 482 781 individuals diagnosed with septicaemia and 1 892 825 age/sex-matched non-septicaemia patients for the comparison. Data were drawn from a population-based nationwide National Health Insurance Research Database Taiwan, from 1 January 2002 to 31 December 2011. The two cohorts of patients with and without septicaemia were followed up for the occurrence of NMSDS. The Cox-proportional hazard regression model was performed to estimate adjusted HR after multivariate adjustment. Results Individuals with septicaemia had a 4.17-fold (95% CI 3.21 to 5.4, p < 0.001) higher risk to develop NMSDS compared with those without septicaemia. Patients aged <65 years had a greater NMSDS risk (<45 years: HR = 6.41, 95% CI 3.65 to 11.3, p < 0.001; 45-64 years: HR = 6.66, 95% CI 3.98 to 11.2, p < 0.001). Furthermore, females with septicaemia and individuals with higher severity of septicaemia were associated with increased risks of developing NMSDS. Conclusions Our results indicated that patients with septicaemia were likely to develop NMSDS. A possible contributing role of septicaemia in increasing the hazard of NMSDS is proposed, based on the outcome that individuals with higher severity of septicaemia carried elevated threat of encountering NMSDS.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalPostgraduate Medical Journal
Volume95
Issue number1124
DOIs
Publication statusPublished - Jun 1 2019

Keywords

  • acute disseminated encephalomyelitis
  • demyelination
  • septicaemia
  • transverse myelitis

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study'. Together they form a unique fingerprint.

  • Cite this

    Chou, C. H., Lee, J. T., Tsai, C. K., Lien, L. M., Yin, J. H., Lin, C. C., Tsai, I. J., Sung, Y. F., Yang, F. C., Tsai, C. L., Wang, I. K., Tseng, C. H., & Hsu, C. Y. (2019). Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study. Postgraduate Medical Journal, 95(1124), 307-313. https://doi.org/10.1136/postgradmedj-2019-136667