Abstract

Objective. Varicella zoster virus (VZV) has been proposed to be involved in the pathogenesis of multiple sclerosis (MS). However, the epidemiological data regarding the MS occurrence rate following herpes zoster are still scanty. The goal of this study is to investigate the frequency and risk for MS following occurrence of herpes zoster. Methods. This study used the Taiwan National Health Insurance Research Database. A total of 315,550 patients with herpes zoster were included as the study group, and the control group consisted of 946,650 randomly selected subjects. The stratified Cox proportional hazard regression was performed to calculate the 1-year MS-free survival rate. Results. Of 1,262,200 sampled patients, 29 from the study group (.009%) and 24 from the control group (.003%) had MS during the 1-year follow-up period. After adjusting for monthly income and geographic region, the hazard of MS was 3.96 times greater (95% CI 5 2.22-7.07, p <0.001) for the study group than controls. Conclusions. Our findings support the notion that occurrence of MS could be associated with herpes zoster attack. We found a significantly higher risk for MS within 1 year of herpes zoster attack compared with the control population.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalJournal of Infectious Diseases
Volume204
Issue number2
DOIs
Publication statusPublished - Jul 15 2011

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Herpes Zoster
Multiple Sclerosis
Population
Control Groups
Human Herpesvirus 3
National Health Programs
Taiwan
Survival Rate
Databases
Research

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

@article{0a7a662dc5b541798af2f8d9be40e73b,
title = "Increased risk of multiple sclerosis following herpes zoster: A nationwide, population-based study",
abstract = "Objective. Varicella zoster virus (VZV) has been proposed to be involved in the pathogenesis of multiple sclerosis (MS). However, the epidemiological data regarding the MS occurrence rate following herpes zoster are still scanty. The goal of this study is to investigate the frequency and risk for MS following occurrence of herpes zoster. Methods. This study used the Taiwan National Health Insurance Research Database. A total of 315,550 patients with herpes zoster were included as the study group, and the control group consisted of 946,650 randomly selected subjects. The stratified Cox proportional hazard regression was performed to calculate the 1-year MS-free survival rate. Results. Of 1,262,200 sampled patients, 29 from the study group (.009{\%}) and 24 from the control group (.003{\%}) had MS during the 1-year follow-up period. After adjusting for monthly income and geographic region, the hazard of MS was 3.96 times greater (95{\%} CI 5 2.22-7.07, p <0.001) for the study group than controls. Conclusions. Our findings support the notion that occurrence of MS could be associated with herpes zoster attack. We found a significantly higher risk for MS within 1 year of herpes zoster attack compared with the control population.",
author = "Kang, {Jiunn Horng} and Sheu, {Jau Jiuan} and Senyeong Kao and Lin, {Herng Ching}",
year = "2011",
month = "7",
day = "15",
doi = "10.1093/infdis/jir239",
language = "English",
volume = "204",
pages = "188--192",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Increased risk of multiple sclerosis following herpes zoster

T2 - A nationwide, population-based study

AU - Kang, Jiunn Horng

AU - Sheu, Jau Jiuan

AU - Kao, Senyeong

AU - Lin, Herng Ching

PY - 2011/7/15

Y1 - 2011/7/15

N2 - Objective. Varicella zoster virus (VZV) has been proposed to be involved in the pathogenesis of multiple sclerosis (MS). However, the epidemiological data regarding the MS occurrence rate following herpes zoster are still scanty. The goal of this study is to investigate the frequency and risk for MS following occurrence of herpes zoster. Methods. This study used the Taiwan National Health Insurance Research Database. A total of 315,550 patients with herpes zoster were included as the study group, and the control group consisted of 946,650 randomly selected subjects. The stratified Cox proportional hazard regression was performed to calculate the 1-year MS-free survival rate. Results. Of 1,262,200 sampled patients, 29 from the study group (.009%) and 24 from the control group (.003%) had MS during the 1-year follow-up period. After adjusting for monthly income and geographic region, the hazard of MS was 3.96 times greater (95% CI 5 2.22-7.07, p <0.001) for the study group than controls. Conclusions. Our findings support the notion that occurrence of MS could be associated with herpes zoster attack. We found a significantly higher risk for MS within 1 year of herpes zoster attack compared with the control population.

AB - Objective. Varicella zoster virus (VZV) has been proposed to be involved in the pathogenesis of multiple sclerosis (MS). However, the epidemiological data regarding the MS occurrence rate following herpes zoster are still scanty. The goal of this study is to investigate the frequency and risk for MS following occurrence of herpes zoster. Methods. This study used the Taiwan National Health Insurance Research Database. A total of 315,550 patients with herpes zoster were included as the study group, and the control group consisted of 946,650 randomly selected subjects. The stratified Cox proportional hazard regression was performed to calculate the 1-year MS-free survival rate. Results. Of 1,262,200 sampled patients, 29 from the study group (.009%) and 24 from the control group (.003%) had MS during the 1-year follow-up period. After adjusting for monthly income and geographic region, the hazard of MS was 3.96 times greater (95% CI 5 2.22-7.07, p <0.001) for the study group than controls. Conclusions. Our findings support the notion that occurrence of MS could be associated with herpes zoster attack. We found a significantly higher risk for MS within 1 year of herpes zoster attack compared with the control population.

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