Increased risk of ischemic stroke in patients with systemic lupus erythematosus:A nationwide population-based study

Chun Chih Chiu, Chin Chou Huang, Wan Leong Chan, Chia Min Chung, Po Hsun Huang, Shing Jong Lin, Jaw Wen Chen, Hsin Bang Leu

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background Systemic lupus erythematosus (SLE) has been reported to be associated with an increased risk of cardiovascular disease. However, most studies have been criticized for either a small sample size or the lack of a prospective control. Our study investigated the relationship of SLE and the subsequent development of ischemic stroke using a nationwide, population-based database in an Asian population. Methods From 2000 to 2007, we identified a study cohort consisting of a total of 11,637 newly diagnosed SLE patients using the National Health Insurance Research Database in Taiwan. A control cohort of 58,185 subjects without SLE, matched for age, gender, and comorbidities were selected for comparison to observe the occurrence of ischemic stroke in these two groups. Results During a follow-up period of up to 7 years, ischemic stroke developed in 258 (2.22%) of the patients with SLE and in 873 (1.5%) of patients in the comparison cohort. Kaplan-Meier analysis also revealed a tendency of SLE patients toward ischemic stroke development (log rank test, p = 0.001). After Cox model adjustment for patients' demographic characteristics and selected comorbidities, patients with SLE were found to have a 1.67-fold (95% CI, 1.45 to 1.91) higher risk of developing ischemic stroke. Conclusion Patients with SLE have an increased risk of stroke.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalInternal Medicine
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 4 2012
Externally publishedYes

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Systemic Lupus Erythematosus
Stroke
Population
Comorbidity
Databases
Kaplan-Meier Estimate
National Health Programs
Taiwan
Proportional Hazards Models
Sample Size
Cohort Studies
Cardiovascular Diseases
Demography
Research

Keywords

  • Stroke
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Increased risk of ischemic stroke in patients with systemic lupus erythematosus:A nationwide population-based study. / Chiu, Chun Chih; Huang, Chin Chou; Chan, Wan Leong; Chung, Chia Min; Huang, Po Hsun; Lin, Shing Jong; Chen, Jaw Wen; Leu, Hsin Bang.

In: Internal Medicine, Vol. 51, No. 1, 04.01.2012, p. 17-21.

Research output: Contribution to journalArticle

Chiu, Chun Chih ; Huang, Chin Chou ; Chan, Wan Leong ; Chung, Chia Min ; Huang, Po Hsun ; Lin, Shing Jong ; Chen, Jaw Wen ; Leu, Hsin Bang. / Increased risk of ischemic stroke in patients with systemic lupus erythematosus:A nationwide population-based study. In: Internal Medicine. 2012 ; Vol. 51, No. 1. pp. 17-21.
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