Increased risk of ischemic stroke among women with bladder pain syndrome/interstitial cystitis: A cohort study from Taiwan

Shiu Dong Chung, Sudha Xirasagar, Ching Chun Lin, Wells Ling, Hsien-Chang Li, Herng Ching Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow-up, compared to controls without a BPS/IC diagnosis.

Methods This retrospective cohort study used data retrieved from the Taiwan "Longitudinal Health Insurance Database 2000." We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow-up.

Results The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78-27.07) and 11.65 (95% CI: 9.88-13.64) per 1,000 person-years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09-2.14) in the BPS/IC group relative to the comparison group over 3-year follow-up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02-2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk.

Conclusions Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan. Neurourol. Urodynam. 34:44-49, 2015.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalNeurourology and Urodynamics
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Interstitial Cystitis
Taiwan
Urinary Bladder
Cohort Studies
Stroke
Pain
Confidence Intervals
Health Insurance
Hyperlipidemias
Chronic Renal Insufficiency
Atrial Fibrillation
Coronary Disease
Retrospective Studies
Regression Analysis
Demography
Databases
Hypertension
Incidence

Keywords

  • bladder pain syndrome/interstitial cystitis
  • interstitial cystitis
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

Cite this

Increased risk of ischemic stroke among women with bladder pain syndrome/interstitial cystitis : A cohort study from Taiwan. / Chung, Shiu Dong; Xirasagar, Sudha; Lin, Ching Chun; Ling, Wells; Li, Hsien-Chang; Lin, Herng Ching.

In: Neurourology and Urodynamics, Vol. 34, No. 1, 01.01.2015, p. 44-49.

Research output: Contribution to journalArticle

Chung, Shiu Dong ; Xirasagar, Sudha ; Lin, Ching Chun ; Ling, Wells ; Li, Hsien-Chang ; Lin, Herng Ching. / Increased risk of ischemic stroke among women with bladder pain syndrome/interstitial cystitis : A cohort study from Taiwan. In: Neurourology and Urodynamics. 2015 ; Vol. 34, No. 1. pp. 44-49.
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N2 - Aim Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow-up, compared to controls without a BPS/IC diagnosis.Methods This retrospective cohort study used data retrieved from the Taiwan "Longitudinal Health Insurance Database 2000." We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow-up.Results The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78-27.07) and 11.65 (95% CI: 9.88-13.64) per 1,000 person-years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09-2.14) in the BPS/IC group relative to the comparison group over 3-year follow-up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02-2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk.Conclusions Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan. Neurourol. Urodynam. 34:44-49, 2015.

AB - Aim Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow-up, compared to controls without a BPS/IC diagnosis.Methods This retrospective cohort study used data retrieved from the Taiwan "Longitudinal Health Insurance Database 2000." We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow-up.Results The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78-27.07) and 11.65 (95% CI: 9.88-13.64) per 1,000 person-years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09-2.14) in the BPS/IC group relative to the comparison group over 3-year follow-up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02-2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk.Conclusions Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan. Neurourol. Urodynam. 34:44-49, 2015.

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