Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss: A nationwide, population-based cohort study

Hsin Te Hsu, Jen Yin Chen, Shih Feng Weng, Kuan Hua Huang, Yong-Song Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVES: Previous studies have proposed that impaired cochlear blood perfusion and microvascular damage are important etiopathogenetic events in the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was to test the hypothesis that SSHL is a risk factor for the development of erectile dysfunction (ED). STUDY DESIGN: A retrospective cohort study. SETTING: Population-based study of Taiwan National Health Insurance Research Database. METHODS: We compared male patients newly diagnosed with SSHL between January 1, 2001, and December 31, 2006 (N = 23,212), with age-matched controls (1:2) (N = 46,424). MAIN OUTCOME MEASURES: The incidence of ED at the end of 2009 was determined. RESULTS: After adjusting for potential confounding factors, we found an adjusted hazard ratio (HR) of 1.942 (95% confidence interval, 1.688-2.233, p <0.05), showing that patients with SSHL were more likely to experience ED than the control population. When stratified by patients' age, the incidence of ED was 1.90-, 2.25-, and 1.84-fold higher for SSHL-diagnosed patients 16 to 34 years old (p = 0.0408), 35 to 49 years old (p <0.0001), and 50 to 64 years old (p <0.0001), respectively, than in the non-SSHL group. Hypertension and chronic renal disease comorbidities in patients with SSHL seemed to be associated with an increased risk of developing ED. CONCLUSION: SSHL may confer an independent risk of ED. This observation supports the assumption of the underlying vascular mechanism regarding the development of SSHL. Thus, clinicians managing SSHL patients should be aware of the potential of the development of ED. EVIDENCE LEVEL: 2B

Original languageEnglish
Pages (from-to)862-867
Number of pages6
JournalOtology and Neurotology
Volume34
Issue number5
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Sudden Hearing Loss
Sensorineural Hearing Loss
Erectile Dysfunction
Cohort Studies
Population
Cochlea
Incidence
National Health Programs
Taiwan
Chronic Renal Insufficiency
Blood Vessels
Comorbidity
Retrospective Studies
Perfusion
Databases
Confidence Intervals
Hypertension

Keywords

  • Erectile dysfunction
  • Sudden deafness
  • Sudden sensorineural hearing loss

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology
  • Sensory Systems
  • Medicine(all)

Cite this

Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss : A nationwide, population-based cohort study. / Hsu, Hsin Te; Chen, Jen Yin; Weng, Shih Feng; Huang, Kuan Hua; Lin, Yong-Song.

In: Otology and Neurotology, Vol. 34, No. 5, 07.2013, p. 862-867.

Research output: Contribution to journalArticle

Hsu, Hsin Te ; Chen, Jen Yin ; Weng, Shih Feng ; Huang, Kuan Hua ; Lin, Yong-Song. / Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss : A nationwide, population-based cohort study. In: Otology and Neurotology. 2013 ; Vol. 34, No. 5. pp. 862-867.
@article{b6bcb0385b054bdfb5d5267e27fce8b0,
title = "Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss: A nationwide, population-based cohort study",
abstract = "OBJECTIVES: Previous studies have proposed that impaired cochlear blood perfusion and microvascular damage are important etiopathogenetic events in the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was to test the hypothesis that SSHL is a risk factor for the development of erectile dysfunction (ED). STUDY DESIGN: A retrospective cohort study. SETTING: Population-based study of Taiwan National Health Insurance Research Database. METHODS: We compared male patients newly diagnosed with SSHL between January 1, 2001, and December 31, 2006 (N = 23,212), with age-matched controls (1:2) (N = 46,424). MAIN OUTCOME MEASURES: The incidence of ED at the end of 2009 was determined. RESULTS: After adjusting for potential confounding factors, we found an adjusted hazard ratio (HR) of 1.942 (95{\%} confidence interval, 1.688-2.233, p <0.05), showing that patients with SSHL were more likely to experience ED than the control population. When stratified by patients' age, the incidence of ED was 1.90-, 2.25-, and 1.84-fold higher for SSHL-diagnosed patients 16 to 34 years old (p = 0.0408), 35 to 49 years old (p <0.0001), and 50 to 64 years old (p <0.0001), respectively, than in the non-SSHL group. Hypertension and chronic renal disease comorbidities in patients with SSHL seemed to be associated with an increased risk of developing ED. CONCLUSION: SSHL may confer an independent risk of ED. This observation supports the assumption of the underlying vascular mechanism regarding the development of SSHL. Thus, clinicians managing SSHL patients should be aware of the potential of the development of ED. EVIDENCE LEVEL: 2B",
keywords = "Erectile dysfunction, Sudden deafness, Sudden sensorineural hearing loss",
author = "Hsu, {Hsin Te} and Chen, {Jen Yin} and Weng, {Shih Feng} and Huang, {Kuan Hua} and Yong-Song Lin",
year = "2013",
month = "7",
doi = "10.1097/MAO.0b013e3182923fd5",
language = "English",
volume = "34",
pages = "862--867",
journal = "Otology and Neurotology",
issn = "1531-7129",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss

T2 - A nationwide, population-based cohort study

AU - Hsu, Hsin Te

AU - Chen, Jen Yin

AU - Weng, Shih Feng

AU - Huang, Kuan Hua

AU - Lin, Yong-Song

PY - 2013/7

Y1 - 2013/7

N2 - OBJECTIVES: Previous studies have proposed that impaired cochlear blood perfusion and microvascular damage are important etiopathogenetic events in the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was to test the hypothesis that SSHL is a risk factor for the development of erectile dysfunction (ED). STUDY DESIGN: A retrospective cohort study. SETTING: Population-based study of Taiwan National Health Insurance Research Database. METHODS: We compared male patients newly diagnosed with SSHL between January 1, 2001, and December 31, 2006 (N = 23,212), with age-matched controls (1:2) (N = 46,424). MAIN OUTCOME MEASURES: The incidence of ED at the end of 2009 was determined. RESULTS: After adjusting for potential confounding factors, we found an adjusted hazard ratio (HR) of 1.942 (95% confidence interval, 1.688-2.233, p <0.05), showing that patients with SSHL were more likely to experience ED than the control population. When stratified by patients' age, the incidence of ED was 1.90-, 2.25-, and 1.84-fold higher for SSHL-diagnosed patients 16 to 34 years old (p = 0.0408), 35 to 49 years old (p <0.0001), and 50 to 64 years old (p <0.0001), respectively, than in the non-SSHL group. Hypertension and chronic renal disease comorbidities in patients with SSHL seemed to be associated with an increased risk of developing ED. CONCLUSION: SSHL may confer an independent risk of ED. This observation supports the assumption of the underlying vascular mechanism regarding the development of SSHL. Thus, clinicians managing SSHL patients should be aware of the potential of the development of ED. EVIDENCE LEVEL: 2B

AB - OBJECTIVES: Previous studies have proposed that impaired cochlear blood perfusion and microvascular damage are important etiopathogenetic events in the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was to test the hypothesis that SSHL is a risk factor for the development of erectile dysfunction (ED). STUDY DESIGN: A retrospective cohort study. SETTING: Population-based study of Taiwan National Health Insurance Research Database. METHODS: We compared male patients newly diagnosed with SSHL between January 1, 2001, and December 31, 2006 (N = 23,212), with age-matched controls (1:2) (N = 46,424). MAIN OUTCOME MEASURES: The incidence of ED at the end of 2009 was determined. RESULTS: After adjusting for potential confounding factors, we found an adjusted hazard ratio (HR) of 1.942 (95% confidence interval, 1.688-2.233, p <0.05), showing that patients with SSHL were more likely to experience ED than the control population. When stratified by patients' age, the incidence of ED was 1.90-, 2.25-, and 1.84-fold higher for SSHL-diagnosed patients 16 to 34 years old (p = 0.0408), 35 to 49 years old (p <0.0001), and 50 to 64 years old (p <0.0001), respectively, than in the non-SSHL group. Hypertension and chronic renal disease comorbidities in patients with SSHL seemed to be associated with an increased risk of developing ED. CONCLUSION: SSHL may confer an independent risk of ED. This observation supports the assumption of the underlying vascular mechanism regarding the development of SSHL. Thus, clinicians managing SSHL patients should be aware of the potential of the development of ED. EVIDENCE LEVEL: 2B

KW - Erectile dysfunction

KW - Sudden deafness

KW - Sudden sensorineural hearing loss

UR - http://www.scopus.com/inward/record.url?scp=84880921178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880921178&partnerID=8YFLogxK

U2 - 10.1097/MAO.0b013e3182923fd5

DO - 10.1097/MAO.0b013e3182923fd5

M3 - Article

C2 - 23739556

AN - SCOPUS:84880921178

VL - 34

SP - 862

EP - 867

JO - Otology and Neurotology

JF - Otology and Neurotology

SN - 1531-7129

IS - 5

ER -