Abstract

Background: Prior studies indicate a possible association between depression and cholecystectomy, but no study has compared the risk of post-operative depressive disorders (DD) after cholecystectomy. This retrospective follow-up study aimed to examine the relationship between cholecystectomy and the risk of DD in patients with gallstones in a population-based database. Methods: Using ambulatory care data from the Longitudinal Health Insurance Database 2000, 6755 patients who received a first-time principal diagnosis of gallstones at the emergency room (ER) were identified. Among them, 1197 underwent cholecystectomy. Each patient was then individually followed-up for two years to identify those who were later diagnosed with DD. Cox proportional hazards regressions were performed to estimate the risk of developing DD between patients with gallstone who did and those who did not undergo cholecystectomy. Results: Of 6755 patients with gallstones, 173 (2.56%) were diagnosed with DD during the two-year follow-up. Among patients who did and those who did not undergo cholecystectomy, 3.51% and 2.36% later developed depressive disorder, respectively. After adjusting for the patient's sex, age and geographic location, the hazard ratio (HR) of DD within two years of gallstone diagnosis was 1.43 (95% CI, 1.02-2.04) for patients who underwent cholecystectomy compared to those who did not. Females, but not males, had a higher the adjusted HR of DD (1.61; 95% CI, 1.08-2.41) for patients who underwent cholecystectomy compared to those who did not. Conclusions: There is an association between cholecystectomy and subsequent risk of DD among females, but not in males.

Original languageEnglish
Article numbere0129962
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 8 2015

Fingerprint

cholelithiasis
Cholecystectomy
Gallstones
Depressive Disorder
Hazards
Emergency rooms
Health insurance
Databases
health insurance
Geographic Locations
risk estimate
Health Insurance
Ambulatory Care
Hospital Emergency Service
Depression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Increased risk of depressive disorder following cholecystectomy for gallstones. / Tsai, Ming Chieh; Chen, Chao Hung; Lee, Hsin Chien; Lin, Herng Ching; Lee, Cha Ze.

In: PLoS One, Vol. 10, No. 6, e0129962, 08.06.2015.

Research output: Contribution to journalArticle

Tsai, Ming Chieh ; Chen, Chao Hung ; Lee, Hsin Chien ; Lin, Herng Ching ; Lee, Cha Ze. / Increased risk of depressive disorder following cholecystectomy for gallstones. In: PLoS One. 2015 ; Vol. 10, No. 6.
@article{f6b7ba273bd54eccbea321a362ee5b36,
title = "Increased risk of depressive disorder following cholecystectomy for gallstones",
abstract = "Background: Prior studies indicate a possible association between depression and cholecystectomy, but no study has compared the risk of post-operative depressive disorders (DD) after cholecystectomy. This retrospective follow-up study aimed to examine the relationship between cholecystectomy and the risk of DD in patients with gallstones in a population-based database. Methods: Using ambulatory care data from the Longitudinal Health Insurance Database 2000, 6755 patients who received a first-time principal diagnosis of gallstones at the emergency room (ER) were identified. Among them, 1197 underwent cholecystectomy. Each patient was then individually followed-up for two years to identify those who were later diagnosed with DD. Cox proportional hazards regressions were performed to estimate the risk of developing DD between patients with gallstone who did and those who did not undergo cholecystectomy. Results: Of 6755 patients with gallstones, 173 (2.56{\%}) were diagnosed with DD during the two-year follow-up. Among patients who did and those who did not undergo cholecystectomy, 3.51{\%} and 2.36{\%} later developed depressive disorder, respectively. After adjusting for the patient's sex, age and geographic location, the hazard ratio (HR) of DD within two years of gallstone diagnosis was 1.43 (95{\%} CI, 1.02-2.04) for patients who underwent cholecystectomy compared to those who did not. Females, but not males, had a higher the adjusted HR of DD (1.61; 95{\%} CI, 1.08-2.41) for patients who underwent cholecystectomy compared to those who did not. Conclusions: There is an association between cholecystectomy and subsequent risk of DD among females, but not in males.",
author = "Tsai, {Ming Chieh} and Chen, {Chao Hung} and Lee, {Hsin Chien} and Lin, {Herng Ching} and Lee, {Cha Ze}",
year = "2015",
month = "6",
day = "8",
doi = "10.1371/journal.pone.0129962",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

TY - JOUR

T1 - Increased risk of depressive disorder following cholecystectomy for gallstones

AU - Tsai, Ming Chieh

AU - Chen, Chao Hung

AU - Lee, Hsin Chien

AU - Lin, Herng Ching

AU - Lee, Cha Ze

PY - 2015/6/8

Y1 - 2015/6/8

N2 - Background: Prior studies indicate a possible association between depression and cholecystectomy, but no study has compared the risk of post-operative depressive disorders (DD) after cholecystectomy. This retrospective follow-up study aimed to examine the relationship between cholecystectomy and the risk of DD in patients with gallstones in a population-based database. Methods: Using ambulatory care data from the Longitudinal Health Insurance Database 2000, 6755 patients who received a first-time principal diagnosis of gallstones at the emergency room (ER) were identified. Among them, 1197 underwent cholecystectomy. Each patient was then individually followed-up for two years to identify those who were later diagnosed with DD. Cox proportional hazards regressions were performed to estimate the risk of developing DD between patients with gallstone who did and those who did not undergo cholecystectomy. Results: Of 6755 patients with gallstones, 173 (2.56%) were diagnosed with DD during the two-year follow-up. Among patients who did and those who did not undergo cholecystectomy, 3.51% and 2.36% later developed depressive disorder, respectively. After adjusting for the patient's sex, age and geographic location, the hazard ratio (HR) of DD within two years of gallstone diagnosis was 1.43 (95% CI, 1.02-2.04) for patients who underwent cholecystectomy compared to those who did not. Females, but not males, had a higher the adjusted HR of DD (1.61; 95% CI, 1.08-2.41) for patients who underwent cholecystectomy compared to those who did not. Conclusions: There is an association between cholecystectomy and subsequent risk of DD among females, but not in males.

AB - Background: Prior studies indicate a possible association between depression and cholecystectomy, but no study has compared the risk of post-operative depressive disorders (DD) after cholecystectomy. This retrospective follow-up study aimed to examine the relationship between cholecystectomy and the risk of DD in patients with gallstones in a population-based database. Methods: Using ambulatory care data from the Longitudinal Health Insurance Database 2000, 6755 patients who received a first-time principal diagnosis of gallstones at the emergency room (ER) were identified. Among them, 1197 underwent cholecystectomy. Each patient was then individually followed-up for two years to identify those who were later diagnosed with DD. Cox proportional hazards regressions were performed to estimate the risk of developing DD between patients with gallstone who did and those who did not undergo cholecystectomy. Results: Of 6755 patients with gallstones, 173 (2.56%) were diagnosed with DD during the two-year follow-up. Among patients who did and those who did not undergo cholecystectomy, 3.51% and 2.36% later developed depressive disorder, respectively. After adjusting for the patient's sex, age and geographic location, the hazard ratio (HR) of DD within two years of gallstone diagnosis was 1.43 (95% CI, 1.02-2.04) for patients who underwent cholecystectomy compared to those who did not. Females, but not males, had a higher the adjusted HR of DD (1.61; 95% CI, 1.08-2.41) for patients who underwent cholecystectomy compared to those who did not. Conclusions: There is an association between cholecystectomy and subsequent risk of DD among females, but not in males.

UR - http://www.scopus.com/inward/record.url?scp=84935418262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84935418262&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0129962

DO - 10.1371/journal.pone.0129962

M3 - Article

C2 - 26053886

AN - SCOPUS:84935418262

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 6

M1 - e0129962

ER -