Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies

Yao Chin Wang, Po An Tai, Tahmina Nasrin Poly, Md Mohaimenul Islam, Hsuan Chia Yang, Chieh Chen Wu, Yu Chuan Jack Li

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Antidepressants are the most commonly and widely used medication for its effectiveness in the treatment of anxiety and depression. A few epidemiological studies have documented that antidepressant is associated with increased risk of dementia so far. Here, our aim is to assess the association between antidepressant use and risk of dementia in elderly patients. We searched articles through MEDLINE, EMBASE, Google, and Google Scholar from inception to December 1, 2017, that reported on the association between antidepressant use and dementia risk. Data were collected from each study independently, and study duplication was checked by at least three senior researchers based on a standardized protocol. Summary relative risk (RR) with 95% CI was calculated by using a random-effects model. We selected 9 out of 754 unique abstracts for full-text review using our predetermined selection criteria, and 5 out of these 9 studies, comprising 53,955 participants, met all of our inclusion criteria. The overall pooled RR of dementia was 1.75 (95% CI: 1.033-2.964) for SSRIs whereas the overall pooled RR of dementia was 2.131 (95% CI: 1.427-3.184) for tricyclic use. Also, MAOIs showed a high rate of increase with significant heterogeneity. Our findings indicate that antidepressant use is significantly associated with an increased risk of developing dementia. Therefore, we suggest physicians to carefully prescribe antidepressants, especially in elder patients. Additionally, treatment should be stopped if any symptoms related to dementia are to be noticed.

Original languageEnglish
Number of pages1
JournalBehavioural Neurology
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Antidepressive Agents
Observational Studies
Dementia
Meta-Analysis
MEDLINE
Patient Selection
Epidemiologic Studies
Anxiety
Research Personnel
Depression
Physicians

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Clinical Neurology

Cite this

Increased Risk of Dementia in Patients with Antidepressants : A Meta-Analysis of Observational Studies. / Wang, Yao Chin; Tai, Po An; Poly, Tahmina Nasrin; Islam, Md Mohaimenul; Yang, Hsuan Chia; Wu, Chieh Chen; Li, Yu Chuan Jack.

In: Behavioural Neurology, Vol. 2018, 01.01.2018.

Research output: Contribution to journalArticle

Wang, Yao Chin ; Tai, Po An ; Poly, Tahmina Nasrin ; Islam, Md Mohaimenul ; Yang, Hsuan Chia ; Wu, Chieh Chen ; Li, Yu Chuan Jack. / Increased Risk of Dementia in Patients with Antidepressants : A Meta-Analysis of Observational Studies. In: Behavioural Neurology. 2018 ; Vol. 2018.
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