Increased risk of concurrent asthma among patients with gastroesophageal reflux disease: A nationwide population-based study

Ming Chieh Tsai, Hsiu Li Lin, Ching Chun Lin, Hsiu Chen Lin, Yi Hua Chen, Stefani Pfeiffer, Herng Ching Lin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aims: The possibility of a relationship between gastroesophageal reflux disease (GERD) and asthma has been controversial. Using a nationwide population-based data set, this study aims to investigate the prevalence and risk of concurrent asthma among GERD patients, compared with patients without GERD in Taiwan. Methods: This study used the National Health Insurance Research Database. A total of 61 941 patients with GERD and 61 941 randomly selected patients without GERD were included from the year 2006. Conditional logistic regression analyses were used to explore the risk of concurrent asthma for patients with and without GERD. Furthermore, the analyses performed were stratified by sex and age (18-44, 45-64, 65-74 and >74 years) to evaluate the association between GERD and concurrent asthma. Results: Of the 123 882 sampled patients, 3% (3681 patients) were diagnosed with asthma in 2006, consisting of 3.9% of the GERD patients (2427 from the study group) and 2% of the patients without GERD (1254 from the comparison group). Conditional logistic regression analysis showed that the odds of concurrent asthma for patients with GERD were 1.97 times greater [95% confidence interval (CI) =1.84-2.12, P

Original languageEnglish
Pages (from-to)1169-1173
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • asthma
  • epidemiology
  • gastroesophageal reflux

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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