TY - JOUR
T1 - Increased risk of chronic fatigue syndrome in patients with migraine
T2 - A retrospective cohort study
AU - Lau, Chi Ieong
AU - Lin, Che Chen
AU - Chen, Wei Hung
AU - Wang, Han Cheng
AU - Kao, Chia Hung
N1 - Funding Information:
This study is supported in part by the Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence ( MOHW104-TDU-B-212-113002 ); China Medical University Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project ( BM104010092 ); NRPB Stroke Clinical Trial Consortium ( MOST 103-2325-B-039 -006 ); Tseng-Lien Lin Foundation , Taichung, Taiwan; Taiwan Brain Disease Foundation , Taipei, Taiwan; Katsuzo and Kiyo Aoshima Memorial Funds , Japan, and CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding received for this study.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Objective: The common concurrence of migraine and chronic fatigue syndrome (CFS) has been reported but whether migraine poses a higher risk of CFS remains unknown. In this retrospective case-control study, we examined the association between the 2 disorders by using a nationwide, population-based database in Taiwan. Methods: The data were retrieved and analyzed from the National Health Insurance Research Database (NHIRD) of Taiwan; 6902 newly diagnosed migraine cases from 2006-2010 were identified in a subset of the NHIRD, and 27,608 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to investigate the risk of CFS in migraineurs after adjustment for demographic characteristics and comorbidities. Results: After adjustment for the covariates, the risk of CFSwas 1.5-fold higher in the migraine cohort than in the comparison cohort (52.72 vs. 28.85 per 10,000 person-years). Intriguingly, the risk was most prominent in the oldest group (≥ 65 years), with a 2.11-fold increased risk (95% confidence interval 1.31-3.41) of CFS. In addition, the adjusted cumulative incidence of CFS in the follow-up years was higher in the migraine group (log-rank test, P <.0001), and CFS incidence appeared to increase with the frequency of migraine diagnoses. Conclusion: The current study demonstrated an increased risk of CFS in migraineurs. Proposed mechanisms in previous studies such as mitochondrial dysfunction and central sensitization may underlie the shared pathophysiology of these seemingly distinct but potentially overlapping disorders.
AB - Objective: The common concurrence of migraine and chronic fatigue syndrome (CFS) has been reported but whether migraine poses a higher risk of CFS remains unknown. In this retrospective case-control study, we examined the association between the 2 disorders by using a nationwide, population-based database in Taiwan. Methods: The data were retrieved and analyzed from the National Health Insurance Research Database (NHIRD) of Taiwan; 6902 newly diagnosed migraine cases from 2006-2010 were identified in a subset of the NHIRD, and 27,608 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to investigate the risk of CFS in migraineurs after adjustment for demographic characteristics and comorbidities. Results: After adjustment for the covariates, the risk of CFSwas 1.5-fold higher in the migraine cohort than in the comparison cohort (52.72 vs. 28.85 per 10,000 person-years). Intriguingly, the risk was most prominent in the oldest group (≥ 65 years), with a 2.11-fold increased risk (95% confidence interval 1.31-3.41) of CFS. In addition, the adjusted cumulative incidence of CFS in the follow-up years was higher in the migraine group (log-rank test, P <.0001), and CFS incidence appeared to increase with the frequency of migraine diagnoses. Conclusion: The current study demonstrated an increased risk of CFS in migraineurs. Proposed mechanisms in previous studies such as mitochondrial dysfunction and central sensitization may underlie the shared pathophysiology of these seemingly distinct but potentially overlapping disorders.
KW - Chronic fatigue syndrome (CFS)
KW - Migraine
KW - Population-based cohort study
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U2 - 10.1016/j.jpsychores.2015.10.005
DO - 10.1016/j.jpsychores.2015.10.005
M3 - Article
AN - SCOPUS:84951103381
SN - 0022-3999
VL - 79
SP - 514
EP - 518
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
IS - 6
ER -
