Increased risk of chronic fatigue syndrome in patients with migraine

A retrospective cohort study

Chi Ieong Lau, Che Chen Lin, Wei Hung Chen, Han Cheng Wang, Chia Hung Kao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The common concurrence of migraine and chronic fatigue syndrome (CFS) has been reported but whether migraine poses a higher risk of CFS remains unknown. In this retrospective case-control study, we examined the association between the 2 disorders by using a nationwide, population-based database in Taiwan. Methods: The data were retrieved and analyzed from the National Health Insurance Research Database (NHIRD) of Taiwan; 6902 newly diagnosed migraine cases from 2006-2010 were identified in a subset of the NHIRD, and 27,608 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to investigate the risk of CFS in migraineurs after adjustment for demographic characteristics and comorbidities. Results: After adjustment for the covariates, the risk of CFSwas 1.5-fold higher in the migraine cohort than in the comparison cohort (52.72 vs. 28.85 per 10,000 person-years). Intriguingly, the risk was most prominent in the oldest group (≥ 65 years), with a 2.11-fold increased risk (95% confidence interval 1.31-3.41) of CFS. In addition, the adjusted cumulative incidence of CFS in the follow-up years was higher in the migraine group (log-rank test, P <.0001), and CFS incidence appeared to increase with the frequency of migraine diagnoses. Conclusion: The current study demonstrated an increased risk of CFS in migraineurs. Proposed mechanisms in previous studies such as mitochondrial dysfunction and central sensitization may underlie the shared pathophysiology of these seemingly distinct but potentially overlapping disorders.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
JournalJournal of Psychosomatic Research
Volume79
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Chronic Fatigue Syndrome
Migraine Disorders
Cohort Studies
Retrospective Studies
National Health Programs
Databases
Taiwan
Central Nervous System Sensitization
Migraine without Aura
Risk Adjustment
Incidence
Proportional Hazards Models
Research
Case-Control Studies
Comorbidity
Demography
Confidence Intervals
Population

Keywords

  • Chronic fatigue syndrome (CFS)
  • Migraine
  • Population-based cohort study

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Increased risk of chronic fatigue syndrome in patients with migraine : A retrospective cohort study. / Lau, Chi Ieong; Lin, Che Chen; Chen, Wei Hung; Wang, Han Cheng; Kao, Chia Hung.

In: Journal of Psychosomatic Research, Vol. 79, No. 6, 01.12.2015, p. 514-518.

Research output: Contribution to journalArticle

Lau, Chi Ieong ; Lin, Che Chen ; Chen, Wei Hung ; Wang, Han Cheng ; Kao, Chia Hung. / Increased risk of chronic fatigue syndrome in patients with migraine : A retrospective cohort study. In: Journal of Psychosomatic Research. 2015 ; Vol. 79, No. 6. pp. 514-518.
@article{46dcd2e9c72647eabc83fc012b438a70,
title = "Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study",
abstract = "Objective: The common concurrence of migraine and chronic fatigue syndrome (CFS) has been reported but whether migraine poses a higher risk of CFS remains unknown. In this retrospective case-control study, we examined the association between the 2 disorders by using a nationwide, population-based database in Taiwan. Methods: The data were retrieved and analyzed from the National Health Insurance Research Database (NHIRD) of Taiwan; 6902 newly diagnosed migraine cases from 2006-2010 were identified in a subset of the NHIRD, and 27,608 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to investigate the risk of CFS in migraineurs after adjustment for demographic characteristics and comorbidities. Results: After adjustment for the covariates, the risk of CFSwas 1.5-fold higher in the migraine cohort than in the comparison cohort (52.72 vs. 28.85 per 10,000 person-years). Intriguingly, the risk was most prominent in the oldest group (≥ 65 years), with a 2.11-fold increased risk (95{\%} confidence interval 1.31-3.41) of CFS. In addition, the adjusted cumulative incidence of CFS in the follow-up years was higher in the migraine group (log-rank test, P <.0001), and CFS incidence appeared to increase with the frequency of migraine diagnoses. Conclusion: The current study demonstrated an increased risk of CFS in migraineurs. Proposed mechanisms in previous studies such as mitochondrial dysfunction and central sensitization may underlie the shared pathophysiology of these seemingly distinct but potentially overlapping disorders.",
keywords = "Chronic fatigue syndrome (CFS), Migraine, Population-based cohort study",
author = "Lau, {Chi Ieong} and Lin, {Che Chen} and Chen, {Wei Hung} and Wang, {Han Cheng} and Kao, {Chia Hung}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.jpsychores.2015.10.005",
language = "English",
volume = "79",
pages = "514--518",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Increased risk of chronic fatigue syndrome in patients with migraine

T2 - A retrospective cohort study

AU - Lau, Chi Ieong

AU - Lin, Che Chen

AU - Chen, Wei Hung

AU - Wang, Han Cheng

AU - Kao, Chia Hung

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Objective: The common concurrence of migraine and chronic fatigue syndrome (CFS) has been reported but whether migraine poses a higher risk of CFS remains unknown. In this retrospective case-control study, we examined the association between the 2 disorders by using a nationwide, population-based database in Taiwan. Methods: The data were retrieved and analyzed from the National Health Insurance Research Database (NHIRD) of Taiwan; 6902 newly diagnosed migraine cases from 2006-2010 were identified in a subset of the NHIRD, and 27,608 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to investigate the risk of CFS in migraineurs after adjustment for demographic characteristics and comorbidities. Results: After adjustment for the covariates, the risk of CFSwas 1.5-fold higher in the migraine cohort than in the comparison cohort (52.72 vs. 28.85 per 10,000 person-years). Intriguingly, the risk was most prominent in the oldest group (≥ 65 years), with a 2.11-fold increased risk (95% confidence interval 1.31-3.41) of CFS. In addition, the adjusted cumulative incidence of CFS in the follow-up years was higher in the migraine group (log-rank test, P <.0001), and CFS incidence appeared to increase with the frequency of migraine diagnoses. Conclusion: The current study demonstrated an increased risk of CFS in migraineurs. Proposed mechanisms in previous studies such as mitochondrial dysfunction and central sensitization may underlie the shared pathophysiology of these seemingly distinct but potentially overlapping disorders.

AB - Objective: The common concurrence of migraine and chronic fatigue syndrome (CFS) has been reported but whether migraine poses a higher risk of CFS remains unknown. In this retrospective case-control study, we examined the association between the 2 disorders by using a nationwide, population-based database in Taiwan. Methods: The data were retrieved and analyzed from the National Health Insurance Research Database (NHIRD) of Taiwan; 6902 newly diagnosed migraine cases from 2006-2010 were identified in a subset of the NHIRD, and 27,608 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to investigate the risk of CFS in migraineurs after adjustment for demographic characteristics and comorbidities. Results: After adjustment for the covariates, the risk of CFSwas 1.5-fold higher in the migraine cohort than in the comparison cohort (52.72 vs. 28.85 per 10,000 person-years). Intriguingly, the risk was most prominent in the oldest group (≥ 65 years), with a 2.11-fold increased risk (95% confidence interval 1.31-3.41) of CFS. In addition, the adjusted cumulative incidence of CFS in the follow-up years was higher in the migraine group (log-rank test, P <.0001), and CFS incidence appeared to increase with the frequency of migraine diagnoses. Conclusion: The current study demonstrated an increased risk of CFS in migraineurs. Proposed mechanisms in previous studies such as mitochondrial dysfunction and central sensitization may underlie the shared pathophysiology of these seemingly distinct but potentially overlapping disorders.

KW - Chronic fatigue syndrome (CFS)

KW - Migraine

KW - Population-based cohort study

UR - http://www.scopus.com/inward/record.url?scp=84951103381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951103381&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychores.2015.10.005

DO - 10.1016/j.jpsychores.2015.10.005

M3 - Article

VL - 79

SP - 514

EP - 518

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

IS - 6

ER -