Increased risk of cancer subsequent to severe depression-A nationwide population-based study

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Empirical findings on the association between a history of depression and subsequent cancer incidence are mixed and inconclusive. A link between depression and cancer would gain greater credence if it can be sustained across cultures. This nationwide, population-based study aimed to prospectively examine the relationship between a psychiatric diagnosis of depression in an inpatient setting and the risk of developing cancer in the following five years in Taiwan. Method: This study used data from the Taiwan National Health Insurance Research Database. A total of 778 patients hospitalized for depression from 1998 to 2003 were recruited, together with 3890 matched non-depressive enrollees as a comparison cohort. Each patient was tracked five years to identify the occurrence of any type of cancer. The Cox proportional hazards models were carried out to compute the risk of cancer between study and comparison cohorts, following adjustment for residence and socio-demographic characteristics. Results: We found that during a five-year follow-up, 61 severely depressed patients (7.8%) and 212 patients in the non-depressed comparison cohort (5.5%) received cancer diagnoses. For adults age 18 and older, having been hospitalized with a diagnosis of depressive disorder was independently associated with a 1.62-fold (95% CI: 1.12, 2.34) overall increased risk of subsequent cancer during five years of follow-up, after adjusting for residence and socio-demographic characteristics. Conclusion: Our results suggest depression is significantly associated with increased risk of cancer in a rather short follow-up time. Our results call attention to the immediate health impacts of severe depression on patients.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalJournal of Affective Disorders
Volume131
Issue number1-3
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Depression
Population
Neoplasms
Taiwan
Demography
National Health Programs
Depressive Disorder
Proportional Hazards Models
Mental Disorders
Inpatients
Cohort Studies
Databases
Incidence
Health
Research

Keywords

  • Cancer risk
  • Depression
  • Prospective studies

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Increased risk of cancer subsequent to severe depression-A nationwide population-based study. / Chen, Yi Hua; Lin, Herng Ching.

In: Journal of Affective Disorders, Vol. 131, No. 1-3, 06.2011, p. 200-206.

Research output: Contribution to journalArticle

@article{dd907fdb5d7047d88eebf3ed9eb5c8f2,
title = "Increased risk of cancer subsequent to severe depression-A nationwide population-based study",
abstract = "Background: Empirical findings on the association between a history of depression and subsequent cancer incidence are mixed and inconclusive. A link between depression and cancer would gain greater credence if it can be sustained across cultures. This nationwide, population-based study aimed to prospectively examine the relationship between a psychiatric diagnosis of depression in an inpatient setting and the risk of developing cancer in the following five years in Taiwan. Method: This study used data from the Taiwan National Health Insurance Research Database. A total of 778 patients hospitalized for depression from 1998 to 2003 were recruited, together with 3890 matched non-depressive enrollees as a comparison cohort. Each patient was tracked five years to identify the occurrence of any type of cancer. The Cox proportional hazards models were carried out to compute the risk of cancer between study and comparison cohorts, following adjustment for residence and socio-demographic characteristics. Results: We found that during a five-year follow-up, 61 severely depressed patients (7.8{\%}) and 212 patients in the non-depressed comparison cohort (5.5{\%}) received cancer diagnoses. For adults age 18 and older, having been hospitalized with a diagnosis of depressive disorder was independently associated with a 1.62-fold (95{\%} CI: 1.12, 2.34) overall increased risk of subsequent cancer during five years of follow-up, after adjusting for residence and socio-demographic characteristics. Conclusion: Our results suggest depression is significantly associated with increased risk of cancer in a rather short follow-up time. Our results call attention to the immediate health impacts of severe depression on patients.",
keywords = "Cancer risk, Depression, Prospective studies",
author = "Chen, {Yi Hua} and Lin, {Herng Ching}",
year = "2011",
month = "6",
doi = "10.1016/j.jad.2010.12.006",
language = "English",
volume = "131",
pages = "200--206",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Increased risk of cancer subsequent to severe depression-A nationwide population-based study

AU - Chen, Yi Hua

AU - Lin, Herng Ching

PY - 2011/6

Y1 - 2011/6

N2 - Background: Empirical findings on the association between a history of depression and subsequent cancer incidence are mixed and inconclusive. A link between depression and cancer would gain greater credence if it can be sustained across cultures. This nationwide, population-based study aimed to prospectively examine the relationship between a psychiatric diagnosis of depression in an inpatient setting and the risk of developing cancer in the following five years in Taiwan. Method: This study used data from the Taiwan National Health Insurance Research Database. A total of 778 patients hospitalized for depression from 1998 to 2003 were recruited, together with 3890 matched non-depressive enrollees as a comparison cohort. Each patient was tracked five years to identify the occurrence of any type of cancer. The Cox proportional hazards models were carried out to compute the risk of cancer between study and comparison cohorts, following adjustment for residence and socio-demographic characteristics. Results: We found that during a five-year follow-up, 61 severely depressed patients (7.8%) and 212 patients in the non-depressed comparison cohort (5.5%) received cancer diagnoses. For adults age 18 and older, having been hospitalized with a diagnosis of depressive disorder was independently associated with a 1.62-fold (95% CI: 1.12, 2.34) overall increased risk of subsequent cancer during five years of follow-up, after adjusting for residence and socio-demographic characteristics. Conclusion: Our results suggest depression is significantly associated with increased risk of cancer in a rather short follow-up time. Our results call attention to the immediate health impacts of severe depression on patients.

AB - Background: Empirical findings on the association between a history of depression and subsequent cancer incidence are mixed and inconclusive. A link between depression and cancer would gain greater credence if it can be sustained across cultures. This nationwide, population-based study aimed to prospectively examine the relationship between a psychiatric diagnosis of depression in an inpatient setting and the risk of developing cancer in the following five years in Taiwan. Method: This study used data from the Taiwan National Health Insurance Research Database. A total of 778 patients hospitalized for depression from 1998 to 2003 were recruited, together with 3890 matched non-depressive enrollees as a comparison cohort. Each patient was tracked five years to identify the occurrence of any type of cancer. The Cox proportional hazards models were carried out to compute the risk of cancer between study and comparison cohorts, following adjustment for residence and socio-demographic characteristics. Results: We found that during a five-year follow-up, 61 severely depressed patients (7.8%) and 212 patients in the non-depressed comparison cohort (5.5%) received cancer diagnoses. For adults age 18 and older, having been hospitalized with a diagnosis of depressive disorder was independently associated with a 1.62-fold (95% CI: 1.12, 2.34) overall increased risk of subsequent cancer during five years of follow-up, after adjusting for residence and socio-demographic characteristics. Conclusion: Our results suggest depression is significantly associated with increased risk of cancer in a rather short follow-up time. Our results call attention to the immediate health impacts of severe depression on patients.

KW - Cancer risk

KW - Depression

KW - Prospective studies

UR - http://www.scopus.com/inward/record.url?scp=79955918265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955918265&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2010.12.006

DO - 10.1016/j.jad.2010.12.006

M3 - Article

C2 - 21242002

AN - SCOPUS:79955918265

VL - 131

SP - 200

EP - 206

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-3

ER -