Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

Ai Ling Shen, Hsiu Li Lin, Hsiu Chen Lin, Yuan Fu Tseng, Chien Yeh Hsu, Che Yi Chou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We hypothesize that autoantibodies are induced after the blood-brain barrier is damaged by stroke and the risk of bullous pemphigoid (BP) is increased after stroke. We assess the risk of BP after first-ever stroke in a nationwide population-based cohort of first-ever stroke patients. Methods: We extracted data from the Longitudinal Health Insurance Database 2005 and identified patients with first-ever stroke as well as control patients matched for age, gender, and year of enrollment. The risk of BP in first-ever stroke patients in comparison with that in control patients was analyzed using Cox regression. Results: Of 12,607 patients with first-ever stroke, 38 (0.3%) patients developed BP in a median of 3.5 years. In the control patients, 8 persons (0.06%) had BP in a median of 3.7 years. The crude hazard ratio (HR) of BP in first-ever stroke patients was 4.83 (95% CI 2.25-10.34, p < 0.001) compared to the control group. The adjusted HR was 4.20 (95% CI 1.94-9.08, p < 0.001) after adjustments for age, gender, hypertension, diabetes, dementia, epilepsy, Parkinson disease, furosemide, and neuroleptics for stroke patients. Conclusions: The risk of BP is increased in first-ever stroke patients in a nationwide population-based cohort and this association is independent of well-known confounders of BP.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalNeurodegenerative Diseases
DOIs
Publication statusAccepted/In press - May 4 2017

Fingerprint

Bullous Pemphigoid
Stroke
Population
Furosemide
Health Insurance
Blood-Brain Barrier
Autoantibodies
Antipsychotic Agents
Parkinson Disease
Dementia
Epilepsy
Databases

Keywords

  • Autoimmune disease
  • Bullous pemphigoid
  • First-ever stroke
  • Health insurance research database
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Increased Risk of Bullous Pemphigoid after First-Ever Stroke : A Population-Based Study. / Shen, Ai Ling; Lin, Hsiu Li; Lin, Hsiu Chen; Tseng, Yuan Fu; Hsu, Chien Yeh; Chou, Che Yi.

In: Neurodegenerative Diseases, 04.05.2017, p. 166-170.

Research output: Contribution to journalArticle

Shen, Ai Ling ; Lin, Hsiu Li ; Lin, Hsiu Chen ; Tseng, Yuan Fu ; Hsu, Chien Yeh ; Chou, Che Yi. / Increased Risk of Bullous Pemphigoid after First-Ever Stroke : A Population-Based Study. In: Neurodegenerative Diseases. 2017 ; pp. 166-170.
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