Increased risk of bladder cancer following diagnosis with bladder pain syndrome/interstitial cystitis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aims Interstitial cystitis/bladder pain syndrome (IC/BPS) is a prevalent disorder that may contribute to bladder cancer (BC). This cohort study set out to investigate the association between IC/BPS and BC by using a population-based dataset. Methods The data for this study were sourced from the Taiwan National Health Insurance program. The case cohort comprised 7,562 patients with IC/BPS, and 22,686 randomly selected subjects were used as a comparison cohort. A Cox proportional hazards regression model (stratified by age group, geographic location, urbanization level, and the index year) was constructed to estimate the risk of subsequent BC following a diagnosis of IC/BPS. We also ran the analysis utilizing an alternative comparison cohort composed of patients with urinary incontinence (UI). Results In the study sample of 30,248 patients, 96 patients (0.32%) received a diagnosis of BC during the 3-year follow-up period; 48 (0.63% of patients with IC/BPS) were from the study cohort; and 48 (0.21% of patients without IC/BPS) were from the comparison cohort. The incidence rate of BC was 2.12 (95% CI: 1.58-2.78) per 1,000 person-years in patients with IC/BPS and 0.70 (95% CI: 0.52-0.92) per 1,000 person-years in comparison patients. Cox proportional analysis revealed that the adjusted HR for BC during the 3-year follow-up period for patients with IC/BPS was 2.95 (95% CI: 1.97-4.41) that of comparison subjects. When performing the analysis with the alternative UI comparison cohort, the adjusted HR for BC was 1.96 (95% CI: 1.14-3.39). Conclusions This investigation detected a novel association between BC and prior IC/BPS. Neurourol. Urodynam. 32: 58-62, 2013. © 2012 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalNeurourology and Urodynamics
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Interstitial Cystitis
Urinary Bladder Neoplasms
Urinary Bladder
Pain
National Health Programs
Urinary Incontinence
Cohort Studies
Geographic Locations
Urbanization
Taiwan
Proportional Hazards Models
Age Groups

Keywords

  • bladder cancer
  • IC/BPS
  • interstitial cystitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

Cite this

Increased risk of bladder cancer following diagnosis with bladder pain syndrome/interstitial cystitis. / Keller, Joseph; Chiou, Hung Yi; Lin, Herng Ching.

In: Neurourology and Urodynamics, Vol. 32, No. 1, 01.2013, p. 58-62.

Research output: Contribution to journalArticle

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title = "Increased risk of bladder cancer following diagnosis with bladder pain syndrome/interstitial cystitis",
abstract = "Aims Interstitial cystitis/bladder pain syndrome (IC/BPS) is a prevalent disorder that may contribute to bladder cancer (BC). This cohort study set out to investigate the association between IC/BPS and BC by using a population-based dataset. Methods The data for this study were sourced from the Taiwan National Health Insurance program. The case cohort comprised 7,562 patients with IC/BPS, and 22,686 randomly selected subjects were used as a comparison cohort. A Cox proportional hazards regression model (stratified by age group, geographic location, urbanization level, and the index year) was constructed to estimate the risk of subsequent BC following a diagnosis of IC/BPS. We also ran the analysis utilizing an alternative comparison cohort composed of patients with urinary incontinence (UI). Results In the study sample of 30,248 patients, 96 patients (0.32{\%}) received a diagnosis of BC during the 3-year follow-up period; 48 (0.63{\%} of patients with IC/BPS) were from the study cohort; and 48 (0.21{\%} of patients without IC/BPS) were from the comparison cohort. The incidence rate of BC was 2.12 (95{\%} CI: 1.58-2.78) per 1,000 person-years in patients with IC/BPS and 0.70 (95{\%} CI: 0.52-0.92) per 1,000 person-years in comparison patients. Cox proportional analysis revealed that the adjusted HR for BC during the 3-year follow-up period for patients with IC/BPS was 2.95 (95{\%} CI: 1.97-4.41) that of comparison subjects. When performing the analysis with the alternative UI comparison cohort, the adjusted HR for BC was 1.96 (95{\%} CI: 1.14-3.39). Conclusions This investigation detected a novel association between BC and prior IC/BPS. Neurourol. Urodynam. 32: 58-62, 2013. {\circledC} 2012 Wiley Periodicals, Inc.",
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AB - Aims Interstitial cystitis/bladder pain syndrome (IC/BPS) is a prevalent disorder that may contribute to bladder cancer (BC). This cohort study set out to investigate the association between IC/BPS and BC by using a population-based dataset. Methods The data for this study were sourced from the Taiwan National Health Insurance program. The case cohort comprised 7,562 patients with IC/BPS, and 22,686 randomly selected subjects were used as a comparison cohort. A Cox proportional hazards regression model (stratified by age group, geographic location, urbanization level, and the index year) was constructed to estimate the risk of subsequent BC following a diagnosis of IC/BPS. We also ran the analysis utilizing an alternative comparison cohort composed of patients with urinary incontinence (UI). Results In the study sample of 30,248 patients, 96 patients (0.32%) received a diagnosis of BC during the 3-year follow-up period; 48 (0.63% of patients with IC/BPS) were from the study cohort; and 48 (0.21% of patients without IC/BPS) were from the comparison cohort. The incidence rate of BC was 2.12 (95% CI: 1.58-2.78) per 1,000 person-years in patients with IC/BPS and 0.70 (95% CI: 0.52-0.92) per 1,000 person-years in comparison patients. Cox proportional analysis revealed that the adjusted HR for BC during the 3-year follow-up period for patients with IC/BPS was 2.95 (95% CI: 1.97-4.41) that of comparison subjects. When performing the analysis with the alternative UI comparison cohort, the adjusted HR for BC was 1.96 (95% CI: 1.14-3.39). Conclusions This investigation detected a novel association between BC and prior IC/BPS. Neurourol. Urodynam. 32: 58-62, 2013. © 2012 Wiley Periodicals, Inc.

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