Increased risk of benign prostate hyperplasia in sleep apnea patients: A nationwide population-based study

Ping Song Chou, Wei Chiao Chang, Wei Po Chou, Mu En Liu, Chiou Lian Lai, Ching Kuan Liu, Yan Chiou Ku, Shih Jen Tsai, Yii Her Chou, Wei Pin Chang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Sleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population. Methods: The study population was identified from Taiwan's National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients. Results: During the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28-4.29, P

Original languageEnglish
Article numbere93081
JournalPLoS One
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 25 2014

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sleep apnea
Sleep Apnea Syndromes
hyperplasia
Hyperplasia
Prostate
Population
hypoxia
Hazards
Health insurance
health insurance
apnea
Sleep
National Health Programs
Apnea
cohort studies
Taiwan
Regression analysis
confidence interval
Cohort Studies
regression analysis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Increased risk of benign prostate hyperplasia in sleep apnea patients : A nationwide population-based study. / Chou, Ping Song; Chang, Wei Chiao; Chou, Wei Po; Liu, Mu En; Lai, Chiou Lian; Liu, Ching Kuan; Ku, Yan Chiou; Tsai, Shih Jen; Chou, Yii Her; Chang, Wei Pin.

In: PLoS One, Vol. 9, No. 3, e93081, 25.03.2014.

Research output: Contribution to journalArticle

Chou, Ping Song ; Chang, Wei Chiao ; Chou, Wei Po ; Liu, Mu En ; Lai, Chiou Lian ; Liu, Ching Kuan ; Ku, Yan Chiou ; Tsai, Shih Jen ; Chou, Yii Her ; Chang, Wei Pin. / Increased risk of benign prostate hyperplasia in sleep apnea patients : A nationwide population-based study. In: PLoS One. 2014 ; Vol. 9, No. 3.
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