Increased risk of benign prostate hyperplasia in sleep apnea patients: A nationwide population-based study

Ping Song Chou; Wei Chiao Chang; Wei Po Chou; Mu En Liu; Chiou Lian Lai; Ching Kuan Liu; Yan Chiou Ku; Shih Jen Tsai; Yii Her Chou; Wei Pin Chang

doi:10.1371/journal.pone.0093081

Increased risk of benign prostate hyperplasia in sleep apnea patients: A nationwide population-based study

Ping Song Chou, Wei Chiao Chang, Wei Po Chou, Mu En Liu, Chiou Lian Lai, Ching Kuan Liu, Yan Chiou Ku, Shih Jen Tsai, Yii Her Chou, Wei Pin Chang

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: Sleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population. Methods: The study population was identified from Taiwan's National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients. Results: During the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28-4.29, P

Original language	English
Article number	e93081
Journal	PLoS One
Volume	9
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0093081
Publication status	Published - Mar 25 2014

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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title = "Increased risk of benign prostate hyperplasia in sleep apnea patients: A nationwide population-based study",

abstract = "Background: Sleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population. Methods: The study population was identified from Taiwan's National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients. Results: During the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28-4.29, P",

author = "Chou, {Ping Song} and Chang, {Wei Chiao} and Chou, {Wei Po} and Liu, {Mu En} and Lai, {Chiou Lian} and Liu, {Ching Kuan} and Ku, {Yan Chiou} and Tsai, {Shih Jen} and Chou, {Yii Her} and Chang, {Wei Pin}",

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AU - Chang, Wei Chiao

AU - Chou, Wei Po

AU - Liu, Mu En

AU - Lai, Chiou Lian

AU - Liu, Ching Kuan

AU - Ku, Yan Chiou

AU - Tsai, Shih Jen

AU - Chou, Yii Her

AU - Chang, Wei Pin

PY - 2014/3/25

Y1 - 2014/3/25

N2 - Background: Sleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population. Methods: The study population was identified from Taiwan's National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients. Results: During the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28-4.29, P

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Increased risk of benign prostate hyperplasia in sleep apnea patients: A nationwide population-based study

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