Increased Risk of Atopic Diseases in the Siblings of Patients with Autism Spectrum Disorder: A Nationwide Population-Based Cohort Study

Ying Xiu Dai, Ying Hsuan Tai, Yun Ting Chang, Tzeng Ji Chen, Mu Hong Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Several studies have shown a strong association between atopic diseases and autism spectrum disorder (ASD). However, the risk of atopic diseases in individuals having ASD-affected siblings has never been investigated. This nationwide population-based cohort study included 2762 individuals with ASD-affected siblings and 11,048 controls. Diagnoses of atopic diseases, including asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis, were ascertained from 1996 or the birth data to the end of 2011. Individuals with ASD-affected siblings had a higher risk for asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and multiple atopic diseases compared with controls. In conclusion, individuals with ASD-affected siblings were more likely than were the controls to develop atopic diseases, suggesting shared familial mechanisms underlying the two conditions.

Original languageEnglish
Pages (from-to)4626-4633
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume49
Issue number11
DOIs
Publication statusPublished - Nov 1 2019

Keywords

  • Atopy
  • Autism spectrum disorder
  • Cohort study
  • Epidemiology
  • Sibling
  • Taiwan’s National Health Insurance Research Database

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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