Increased risk of adverse pregnancy outcomes in women with rheumatoid arthritis: A nationwide population-based study

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Abstract

Objective: Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes. Methods: The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups. Results: Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95% CI 1.22 to 1.78), 1.20 (95% CI 1.05 to 1.38), 2.22 (95% CI 1.59 to 3.11) and 1.19 (95% CI 1.07 to 1.31) times, respectively, that of comparison mothers. Conclusion: Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.

Original languageEnglish
Pages (from-to)715-717
Number of pages3
JournalAnnals of the Rheumatic Diseases
Volume69
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Pregnancy Outcome
Rheumatoid Arthritis
Pre-Eclampsia
Cesarean Section
Health insurance
Small for Gestational Age Infant
Mothers
Population
Logistics
Regression Analysis
Birth Certificates
Premature Birth
National Health Programs
Taiwan
Gestational Age
Registries
Logistic Models
Databases
Research

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Cite this

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title = "Increased risk of adverse pregnancy outcomes in women with rheumatoid arthritis: A nationwide population-based study",
abstract = "Objective: Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes. Methods: The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups. Results: Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95{\%} CI 1.22 to 1.78), 1.20 (95{\%} CI 1.05 to 1.38), 2.22 (95{\%} CI 1.59 to 3.11) and 1.19 (95{\%} CI 1.07 to 1.31) times, respectively, that of comparison mothers. Conclusion: Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.",
author = "Lin, {Herng Ching} and Chen, {Shu Fen} and Lin, {Hsiu Chen} and Chen, {Yi Hua}",
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AU - Chen, Yi Hua

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N2 - Objective: Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes. Methods: The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups. Results: Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95% CI 1.22 to 1.78), 1.20 (95% CI 1.05 to 1.38), 2.22 (95% CI 1.59 to 3.11) and 1.19 (95% CI 1.07 to 1.31) times, respectively, that of comparison mothers. Conclusion: Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.

AB - Objective: Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes. Methods: The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups. Results: Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95% CI 1.22 to 1.78), 1.20 (95% CI 1.05 to 1.38), 2.22 (95% CI 1.59 to 3.11) and 1.19 (95% CI 1.07 to 1.31) times, respectively, that of comparison mothers. Conclusion: Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.

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