Increased risk of adverse pregnancy outcomes for hospitalisation of women with lupus during pregnancy: A nationwide population-based study

C. Y. Chen, Y. H. Chen, H. C. Lin, S. F. Chen, Herng Ching Lin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: Using a nationwide population-based dataset to examine the risk of adverse pregnancy outcomes in women with systemic lupus erythematosus (SLE), with and without SLE hospitalisation during pregnancy. Methods: We identified 1,010 pregnant women who had SLE during 2001-2003 as the study cohort and 5,050 randomly selected pregnant women (five for every woman with SLE) as a comparison cohort. Conditional logistic regression analyses were performed to explore the relationship between women with and without SLE and the risk of low birth weight (LBW), preterm birth, and babies small for gestational age (SGA), after adjusting for the characteristics of the infant, mother, and father. Results: We found that there were significant differences in the risk of LBW (14.9% vs. 7.2%), preterm birth (14.4% vs. 8.5%), and SGA (28.5% vs. 17.5%) for women with SLE compared to women without. In addition, the adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE during pregnancy were 6.15 (95% CI=4.15-9.13), 4.19 (95% CI=2.77-6.36), and 4.25 (95% CI=2.95-6.11) times, respectively, compared to women without any chronic illness. The adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE but were not hospitalized during pregnancy were 1.80 (95% CI=1.43-2.26), 1.62 (95% CI=1.30-2.03), and 1.63 (95% CI=1.38-1.94) times, respectively, compared to unaffected mothers. Conclusion: We conclude that SLE can impact the pregnancy outcomes, especially if hospitalisation occurs during the pregnancy.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalClinical and Experimental Rheumatology
Volume28
Issue number1
Publication statusPublished - 2010

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Pregnancy Outcome
Systemic Lupus Erythematosus
Hospitalization
Pregnancy
Premature Birth
Low Birth Weight Infant
Population
Gestational Age
Pregnant Women
Mothers
Fathers
Chronic Disease
Cohort Studies
Logistic Models
Regression Analysis

Keywords

  • Low birth weight
  • Pregnancy outcome
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

@article{14197d7dc656445f863b848f4013bf47,
title = "Increased risk of adverse pregnancy outcomes for hospitalisation of women with lupus during pregnancy: A nationwide population-based study",
abstract = "Objective: Using a nationwide population-based dataset to examine the risk of adverse pregnancy outcomes in women with systemic lupus erythematosus (SLE), with and without SLE hospitalisation during pregnancy. Methods: We identified 1,010 pregnant women who had SLE during 2001-2003 as the study cohort and 5,050 randomly selected pregnant women (five for every woman with SLE) as a comparison cohort. Conditional logistic regression analyses were performed to explore the relationship between women with and without SLE and the risk of low birth weight (LBW), preterm birth, and babies small for gestational age (SGA), after adjusting for the characteristics of the infant, mother, and father. Results: We found that there were significant differences in the risk of LBW (14.9{\%} vs. 7.2{\%}), preterm birth (14.4{\%} vs. 8.5{\%}), and SGA (28.5{\%} vs. 17.5{\%}) for women with SLE compared to women without. In addition, the adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE during pregnancy were 6.15 (95{\%} CI=4.15-9.13), 4.19 (95{\%} CI=2.77-6.36), and 4.25 (95{\%} CI=2.95-6.11) times, respectively, compared to women without any chronic illness. The adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE but were not hospitalized during pregnancy were 1.80 (95{\%} CI=1.43-2.26), 1.62 (95{\%} CI=1.30-2.03), and 1.63 (95{\%} CI=1.38-1.94) times, respectively, compared to unaffected mothers. Conclusion: We conclude that SLE can impact the pregnancy outcomes, especially if hospitalisation occurs during the pregnancy.",
keywords = "Low birth weight, Pregnancy outcome, Systemic lupus erythematosus",
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T1 - Increased risk of adverse pregnancy outcomes for hospitalisation of women with lupus during pregnancy

T2 - A nationwide population-based study

AU - Chen, C. Y.

AU - Chen, Y. H.

AU - Lin, H. C.

AU - Chen, S. F.

AU - Lin, Herng Ching

PY - 2010

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N2 - Objective: Using a nationwide population-based dataset to examine the risk of adverse pregnancy outcomes in women with systemic lupus erythematosus (SLE), with and without SLE hospitalisation during pregnancy. Methods: We identified 1,010 pregnant women who had SLE during 2001-2003 as the study cohort and 5,050 randomly selected pregnant women (five for every woman with SLE) as a comparison cohort. Conditional logistic regression analyses were performed to explore the relationship between women with and without SLE and the risk of low birth weight (LBW), preterm birth, and babies small for gestational age (SGA), after adjusting for the characteristics of the infant, mother, and father. Results: We found that there were significant differences in the risk of LBW (14.9% vs. 7.2%), preterm birth (14.4% vs. 8.5%), and SGA (28.5% vs. 17.5%) for women with SLE compared to women without. In addition, the adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE during pregnancy were 6.15 (95% CI=4.15-9.13), 4.19 (95% CI=2.77-6.36), and 4.25 (95% CI=2.95-6.11) times, respectively, compared to women without any chronic illness. The adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE but were not hospitalized during pregnancy were 1.80 (95% CI=1.43-2.26), 1.62 (95% CI=1.30-2.03), and 1.63 (95% CI=1.38-1.94) times, respectively, compared to unaffected mothers. Conclusion: We conclude that SLE can impact the pregnancy outcomes, especially if hospitalisation occurs during the pregnancy.

AB - Objective: Using a nationwide population-based dataset to examine the risk of adverse pregnancy outcomes in women with systemic lupus erythematosus (SLE), with and without SLE hospitalisation during pregnancy. Methods: We identified 1,010 pregnant women who had SLE during 2001-2003 as the study cohort and 5,050 randomly selected pregnant women (five for every woman with SLE) as a comparison cohort. Conditional logistic regression analyses were performed to explore the relationship between women with and without SLE and the risk of low birth weight (LBW), preterm birth, and babies small for gestational age (SGA), after adjusting for the characteristics of the infant, mother, and father. Results: We found that there were significant differences in the risk of LBW (14.9% vs. 7.2%), preterm birth (14.4% vs. 8.5%), and SGA (28.5% vs. 17.5%) for women with SLE compared to women without. In addition, the adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE during pregnancy were 6.15 (95% CI=4.15-9.13), 4.19 (95% CI=2.77-6.36), and 4.25 (95% CI=2.95-6.11) times, respectively, compared to women without any chronic illness. The adjusted odds of LBW, preterm birth, and SGA babies for women who had SLE but were not hospitalized during pregnancy were 1.80 (95% CI=1.43-2.26), 1.62 (95% CI=1.30-2.03), and 1.63 (95% CI=1.38-1.94) times, respectively, compared to unaffected mothers. Conclusion: We conclude that SLE can impact the pregnancy outcomes, especially if hospitalisation occurs during the pregnancy.

KW - Low birth weight

KW - Pregnancy outcome

KW - Systemic lupus erythematosus

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