Increased risk of acute myocardial infarction in patients with psoriasis: A 5-year population-based study in Taiwan

Hui Wen Lin, Kuo Hsien Wang, Hsiu Chen Lin, Herng Ching Lin

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Abstract

Background: No previous study has investigated the incidence or risk of acute myocardial infarction (AMI) developing after the diagnosis of psoriasis in Asian populations. Objective: We sought to evaluate the association between psoriasis and subsequent AMI during a 5-year follow-up period, using a nationwide Taiwanese population-based claims database, and taking clinical and demographic characteristics into consideration. Methods: Our study cohort consisted of all patients with a first recorded diagnosis of psoriasis (N = 4752) between 1999 and 2001 and of patients without a diagnosis of psoriasis (N = 23,760) who were matched by age and sex (1:5) to the patients with psoriasis. Each patient was tracked using hospitalization data from 2001 until the end of 2006. Stratified Cox proportional hazard regressions (stratified by age and sex) were performed as a means of computing the 5-year AMI-free survivals after adjusting for possible confounding factors. Results: Of the total sample, 70 patients (0.2%) had AMIs during the 5-year follow-up period: 22 (0.5% of the patients with psoriasis) from the study cohort and 48 (0.2%) from the comparison cohort. After adjusting for other factors, the hazard of AMI during the 5-year follow-up period was 2.10 times greater (95% confidence interval 1.27-3.43, P = .004) for patients with psoriasis than for comparison patients. Limitations: We could not take into account some known risk factors for AMI, such as smoking and body mass index. Conclusions: Psoriasis may confer an independent risk of AMI in Asian populations. We suggest that patients with psoriasis be made aware of the increased risk of AMI.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume64
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Taiwan
Psoriasis
Myocardial Infarction
Population
Cohort Studies
Hospitalization
Body Mass Index
Smoking
Demography
Databases
Confidence Intervals
Survival
Incidence

Keywords

  • acute myocardial infarction
  • Asian
  • data set
  • epidemiology
  • psoriasis
  • race
  • stratified Cox proportional hazard regression

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{34f56a1c38494ec38e38bdff79639090,
title = "Increased risk of acute myocardial infarction in patients with psoriasis: A 5-year population-based study in Taiwan",
abstract = "Background: No previous study has investigated the incidence or risk of acute myocardial infarction (AMI) developing after the diagnosis of psoriasis in Asian populations. Objective: We sought to evaluate the association between psoriasis and subsequent AMI during a 5-year follow-up period, using a nationwide Taiwanese population-based claims database, and taking clinical and demographic characteristics into consideration. Methods: Our study cohort consisted of all patients with a first recorded diagnosis of psoriasis (N = 4752) between 1999 and 2001 and of patients without a diagnosis of psoriasis (N = 23,760) who were matched by age and sex (1:5) to the patients with psoriasis. Each patient was tracked using hospitalization data from 2001 until the end of 2006. Stratified Cox proportional hazard regressions (stratified by age and sex) were performed as a means of computing the 5-year AMI-free survivals after adjusting for possible confounding factors. Results: Of the total sample, 70 patients (0.2{\%}) had AMIs during the 5-year follow-up period: 22 (0.5{\%} of the patients with psoriasis) from the study cohort and 48 (0.2{\%}) from the comparison cohort. After adjusting for other factors, the hazard of AMI during the 5-year follow-up period was 2.10 times greater (95{\%} confidence interval 1.27-3.43, P = .004) for patients with psoriasis than for comparison patients. Limitations: We could not take into account some known risk factors for AMI, such as smoking and body mass index. Conclusions: Psoriasis may confer an independent risk of AMI in Asian populations. We suggest that patients with psoriasis be made aware of the increased risk of AMI.",
keywords = "acute myocardial infarction, Asian, data set, epidemiology, psoriasis, race, stratified Cox proportional hazard regression",
author = "Lin, {Hui Wen} and Wang, {Kuo Hsien} and Lin, {Hsiu Chen} and Lin, {Herng Ching}",
year = "2011",
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TY - JOUR

T1 - Increased risk of acute myocardial infarction in patients with psoriasis

T2 - A 5-year population-based study in Taiwan

AU - Lin, Hui Wen

AU - Wang, Kuo Hsien

AU - Lin, Hsiu Chen

AU - Lin, Herng Ching

PY - 2011/3

Y1 - 2011/3

N2 - Background: No previous study has investigated the incidence or risk of acute myocardial infarction (AMI) developing after the diagnosis of psoriasis in Asian populations. Objective: We sought to evaluate the association between psoriasis and subsequent AMI during a 5-year follow-up period, using a nationwide Taiwanese population-based claims database, and taking clinical and demographic characteristics into consideration. Methods: Our study cohort consisted of all patients with a first recorded diagnosis of psoriasis (N = 4752) between 1999 and 2001 and of patients without a diagnosis of psoriasis (N = 23,760) who were matched by age and sex (1:5) to the patients with psoriasis. Each patient was tracked using hospitalization data from 2001 until the end of 2006. Stratified Cox proportional hazard regressions (stratified by age and sex) were performed as a means of computing the 5-year AMI-free survivals after adjusting for possible confounding factors. Results: Of the total sample, 70 patients (0.2%) had AMIs during the 5-year follow-up period: 22 (0.5% of the patients with psoriasis) from the study cohort and 48 (0.2%) from the comparison cohort. After adjusting for other factors, the hazard of AMI during the 5-year follow-up period was 2.10 times greater (95% confidence interval 1.27-3.43, P = .004) for patients with psoriasis than for comparison patients. Limitations: We could not take into account some known risk factors for AMI, such as smoking and body mass index. Conclusions: Psoriasis may confer an independent risk of AMI in Asian populations. We suggest that patients with psoriasis be made aware of the increased risk of AMI.

AB - Background: No previous study has investigated the incidence or risk of acute myocardial infarction (AMI) developing after the diagnosis of psoriasis in Asian populations. Objective: We sought to evaluate the association between psoriasis and subsequent AMI during a 5-year follow-up period, using a nationwide Taiwanese population-based claims database, and taking clinical and demographic characteristics into consideration. Methods: Our study cohort consisted of all patients with a first recorded diagnosis of psoriasis (N = 4752) between 1999 and 2001 and of patients without a diagnosis of psoriasis (N = 23,760) who were matched by age and sex (1:5) to the patients with psoriasis. Each patient was tracked using hospitalization data from 2001 until the end of 2006. Stratified Cox proportional hazard regressions (stratified by age and sex) were performed as a means of computing the 5-year AMI-free survivals after adjusting for possible confounding factors. Results: Of the total sample, 70 patients (0.2%) had AMIs during the 5-year follow-up period: 22 (0.5% of the patients with psoriasis) from the study cohort and 48 (0.2%) from the comparison cohort. After adjusting for other factors, the hazard of AMI during the 5-year follow-up period was 2.10 times greater (95% confidence interval 1.27-3.43, P = .004) for patients with psoriasis than for comparison patients. Limitations: We could not take into account some known risk factors for AMI, such as smoking and body mass index. Conclusions: Psoriasis may confer an independent risk of AMI in Asian populations. We suggest that patients with psoriasis be made aware of the increased risk of AMI.

KW - acute myocardial infarction

KW - Asian

KW - data set

KW - epidemiology

KW - psoriasis

KW - race

KW - stratified Cox proportional hazard regression

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