TY - JOUR
T1 - Increased risk of acute myocardial infarction and mortality in patients with systemic lupus erythematosus
T2 - Two nationwide retrospective cohort studies
AU - Lin, Chiao Yi
AU - Shih, Chun Chuan
AU - Yeh, Chun Chieh
AU - Chou, Wan Hsin
AU - Chen, Ta-Liang
AU - Liao, Chien-Chang
N1 - Funding Information:
This study was supported in part by a grant from the National Science Council Taiwan ( NSC102-2314-B-038-021-MY3 ).
Publisher Copyright:
© 2014 Elsevier Ireland Ltd. All rights reserved.
PY - 2014/10/20
Y1 - 2014/10/20
N2 - Background This study evaluated the risk of acute myocardial infarction (AMI) and mortality among patients with systemic lupus erythematosus (SLE) in two nationwide retrospective cohort studies.Results During the follow-up period, there were 52 newly diagnosed AMI cases. The incidences of AMI for SLE cohort and non-SLE cohort were 2.10 and 0.49 per 1000 person-years, respectively, with an adjusted hazard ratio (HR) of 5.11 (95% confidence interval [CI] 2.63-9.92). For females, the adjusted HR of AMI associated with SLE was as high as 6.28 (95% CI 2.67-14.7). Further analyses in the nested cohort showed that SLE was significantly associated with post-AMI mortality (odds ratio, 2.60; 95% CI 1.09-6.19). Conclusion Patients with SLE had higher risk of AMI compared with non-SLE control, and this risk was more significant in females. In addition, SLE is an independent risk factor for post-AMI mortality.Methods Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study and identified 1207 adults newly diagnosed with SLE in 2000-2004. Non-SLE cohort consisted of 9656 adults without SLE, frequency-matched for age and sex and randomly selected from the same data set. Events of AMI were considered as outcome during the follow-up period between 2000 and 2008. Another nested cohort study of 6900 patients with AMI receiving cardiac surgeries was conducted to analyze the impact of SLE on post-AMI mortality.
AB - Background This study evaluated the risk of acute myocardial infarction (AMI) and mortality among patients with systemic lupus erythematosus (SLE) in two nationwide retrospective cohort studies.Results During the follow-up period, there were 52 newly diagnosed AMI cases. The incidences of AMI for SLE cohort and non-SLE cohort were 2.10 and 0.49 per 1000 person-years, respectively, with an adjusted hazard ratio (HR) of 5.11 (95% confidence interval [CI] 2.63-9.92). For females, the adjusted HR of AMI associated with SLE was as high as 6.28 (95% CI 2.67-14.7). Further analyses in the nested cohort showed that SLE was significantly associated with post-AMI mortality (odds ratio, 2.60; 95% CI 1.09-6.19). Conclusion Patients with SLE had higher risk of AMI compared with non-SLE control, and this risk was more significant in females. In addition, SLE is an independent risk factor for post-AMI mortality.Methods Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study and identified 1207 adults newly diagnosed with SLE in 2000-2004. Non-SLE cohort consisted of 9656 adults without SLE, frequency-matched for age and sex and randomly selected from the same data set. Events of AMI were considered as outcome during the follow-up period between 2000 and 2008. Another nested cohort study of 6900 patients with AMI receiving cardiac surgeries was conducted to analyze the impact of SLE on post-AMI mortality.
KW - Mortality
KW - Myocardial infarction
KW - Systemic lupus erythematosus
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U2 - 10.1016/j.ijcard.2014.08.006
DO - 10.1016/j.ijcard.2014.08.006
M3 - Article
C2 - 25156834
AN - SCOPUS:84908203908
SN - 0167-5273
VL - 176
SP - 847
EP - 851
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -