Increased risk for second primary malignancies in women with breast cancer diagnosed at young age

A population-based study in Taiwan

Kuan Der Lee, Shin Cheh Chen, Chunghuang Hubert Chan, Chang Hsien Lu, Chih G. Chen, Jen Tsun Lin, Miao Fen Chen, Shih Hao Huang, Chun Ming Yeh, Min Chi Chen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Studies conducted in Western countries have reported excess risks for second primary malignancies after breast cancer. However, there is little documentation of ethnic differences in these excess risks. Asian women are characterized by younger age at diagnosis of breast cancer, but very few reports are available on the incidences and risks for second primary cancers in this region. Using population-based data from the Taiwan National Cancer Registry (TNCR) for the period 1979 to 2003, we quantified standardized incidence ratios and cumulative incidence of second cancers among 53,783 women with initial diagnoses of breast cancer. Age-specific incidences showed peaks among women in their 40s, and 1,085 cases (2.02%) developed nonbreast second primary cancers. The risk for second cancers differs significantly according to age at diagnosis of breast cancer. In comparison with women diagnosed when ≥50 years (standardized incidence ratio, 0.96; 95% confidence interval; 0.89-1.04), there were significantly greater risks for bone, corpus uterine, ovarian, thyroid, esophageal, kidney and lung cancers, nonmelanoma skin cancer, and leukemia or lymphoma in women diagnosed when <50 years (standardized incidence ratio, 1.43; 95% confidence interval, 1.29-1.58). The survival probabilities differed between breast cancer patients with and without second cancers (P < 0.001). After diagnosis of the second cancer, the median survival time was only 2.87 years. In conclusion, we confirmed that young age at diagnosis of breast cancer predicted a subsequently increased risk for second malignancies, and the second cancers indeed worsen survivorship in patients who survived breast cancer.

Original languageEnglish
Pages (from-to)2647-2655
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

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Second Primary Neoplasms
Taiwan
Breast Neoplasms
Population
Incidence
Skin Neoplasms
Confidence Intervals
Uterine Neoplasms
Survival
Kidney Neoplasms
Esophageal Neoplasms
Thyroid Neoplasms
Documentation
Ovarian Neoplasms
Registries
Lymphoma
Lung Neoplasms
Leukemia
Survival Rate
Bone and Bones

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Increased risk for second primary malignancies in women with breast cancer diagnosed at young age : A population-based study in Taiwan. / Lee, Kuan Der; Chen, Shin Cheh; Chan, Chunghuang Hubert; Lu, Chang Hsien; Chen, Chih G.; Lin, Jen Tsun; Chen, Miao Fen; Huang, Shih Hao; Yeh, Chun Ming; Chen, Min Chi.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 17, No. 10, 10.2008, p. 2647-2655.

Research output: Contribution to journalArticle

Lee, Kuan Der ; Chen, Shin Cheh ; Chan, Chunghuang Hubert ; Lu, Chang Hsien ; Chen, Chih G. ; Lin, Jen Tsun ; Chen, Miao Fen ; Huang, Shih Hao ; Yeh, Chun Ming ; Chen, Min Chi. / Increased risk for second primary malignancies in women with breast cancer diagnosed at young age : A population-based study in Taiwan. In: Cancer Epidemiology Biomarkers and Prevention. 2008 ; Vol. 17, No. 10. pp. 2647-2655.
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