Increased percentage of B cells in patients with more advanced hepatocellular carcinoma

Jiunn Chang Lin, Yung Luen Shih, Pei Ju Chien, Chien Liang Liu, Jie Jen Lee, Tsan Pai Liu, Wen Ching Ko, Chwen Ming Shih

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To compare immunologic phenotypes between (1) hepatocellular carcinoma (HCC) patients and a healthy population and (2) more advanced and early stage HCC patients, we studied 45 HCC patients and 46 healthy controls from January 2006 to January 2008. Using fluorescent activated cell sorter (FACS) analysis, HCC patients were demonstrated to exhibit stronger phagocytosis of granulocytes and monocytes and more peripheral blood mononuclear cells (PBMCs) in the G2/M phase compared with healthy volunteers. By contrast, lower percentages of B and Th lymphocytes were also found in the peripheral blood of HCC patients than in the healthy population. Most importantly, a higher percentage of B cells was found in patients with advanced HCC than in those with early HCC in terms of TNM stage (II and III vs I, p = 0.004), the Japanese Integrated Scoring system (2-3 vs 0-1, p = 0.0235), and tumor numbers (≥2 vs 1, p = 0.005). In conclusion, our findings suggested that HCC patients might exhibit enhanced innate immunity and reduced adaptive immunity compared with healthy volunteers. A higher percentage of B cells was found in patients with more advanced HCC compared with patients with early stage HCC, which might serve as an indicator of the severity of HCC.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalHuman Immunology
Volume71
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • B lymphocyte
  • Hepatocellular carcinoma
  • Immunity
  • Lymphocyte subset
  • Phagocytosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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  • Cite this

    Lin, J. C., Shih, Y. L., Chien, P. J., Liu, C. L., Lee, J. J., Liu, T. P., Ko, W. C., & Shih, C. M. (2010). Increased percentage of B cells in patients with more advanced hepatocellular carcinoma. Human Immunology, 71(1), 58-62. https://doi.org/10.1016/j.humimm.2009.10.003