Increased levels of circulating advanced glycation end-products in menopausal women with osteoporosis

Deng Ho Yang, Tsay I. Chiang, I. Chang Chang, Fu Huang Lin, Cheng Chung Wei, Ya Wen Cheng

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Advanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing and diabetes. Increased levels of AGEs are found in the bone tissue of patients with osteoporosis. The purpose of this study was to evaluate circulating AGEs in patients with osteoporosis. Methods: We evaluated plasma AGEs, osteoporosis-related biomarkers, and bone mass in 82 menopausal women with osteoporosis or osteopenia, 16 young women with osteopenia, and 43 healthy women without osteoporosis or osteopenia. Results: Higher levels of serum AGEs were found in the osteoporosis or osteopenia group compared to healthy women (P <0.0001). A negative correlation was observed between serum AGEs and lumbar spine bone density (BMD of lumbar spine, r = -0.249, P = 0.028; T-score of lumbar spine, r = -0.261, P = 0.021). Women with a increased level of serum AGEs (> 8.12 U/mL) had a 5.34-fold risk of osteopenia regarding lumbar spine T-score and a 3.31-fold risk of osteopenia regarding the hip T-score. Conclusion: Serum AGEs could be used to monitor the severity and progression of osteoporosis. An increased serum level of AGEs was associated with impaired bone formation and was a risk factor for the development of osteoporosis. Targeting AGEs may represent a novel therapeutic approach for primary or secondary osteoporosis.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalInternational Journal of Medical Sciences
Volume11
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Advanced glycation end-products
  • Biomarker
  • Osteopenia
  • Osteopontin
  • Osteoporosis

ASJC Scopus subject areas

  • Medicine(all)

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