Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina

Ming Jui Hung, Wen Jin Cherng, Ming Yow Hung, Li Tang Kuo, Chi Wen Cheng, Chao Hung Wang, Ning I. Yang, James K. Liao

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: Although inhibition of Rho-associated coiled-coil containing protein kinase (ROCK) has been shown to prevent coronary vasospastic angina (CVA), direct evidence linking ROCK activity and CVA is lacking. Accordingly, we investigated whether ROCK activity is an independent marker for CVA and is altered after treatment with antispastic medications. Methods and results: We prospectively studied 31 Taiwanese patients who were diagnosed with CVA and 33 control subjects. Subject demographics were recorded, and blood samples were obtained at baseline in all participants and in CVA patients after 3 months of antispastic treatment. Compared with control subjects, leukocyte ROCK activity was greater in CVA patients (136% versus 91%, P

Original languageEnglish
Pages (from-to)521-526
Number of pages6
JournalAtherosclerosis
Volume221
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Angina
  • Calcium antagonist
  • Coronary vasospasm
  • Rho-kinase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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