Increased incidence of peptic ulcer disease in central serous chorioretinopathy patients: A population-based retrospective cohort study

San Ni Chen, Iebin Lian, Yi Chiao Chen, Jau Der Ho

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

PURPOSE:: To investigate peptic ulcer disease and other possible risk factors in patients with central serous chorioretinopathy (CSR) using a population-based database. METHODS:: In this population-based retrospective cohort study, longitudinal data from the Taiwan National Health Insurance Research Database were analyzed. The study cohort comprised 835 patients with CSR and the control cohort comprised 4175 patients without CSR from January 2000 to December 2009. Conditional logistic regression was applied to examine the association of peptic ulcer disease and other possible risk factors for CSR, and stratified Cox regression models were applied to examine whether patients with CSR have an increased chance of peptic ulcer disease and hypertension development. RESULTS:: The identifiable risk factors for CSR included peptic ulcer disease (adjusted odd ratio: 1.39, P = 0.001) and higher monthly income (adjusted odd ratio: 1.30, P = 0.006). Patients with CSR also had a significantly higher chance of developing peptic ulcer disease after the diagnosis of CSR (adjusted odd ratio: 1.43, P = 0.009). CONCLUSION:: Peptic ulcer disease and higher monthly income are independent risk factors for CSR. Whereas, patients with CSR also had increased risk for peptic ulcer development.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalRetina
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 6 2015

Fingerprint

Central Serous Chorioretinopathy
Peptic Ulcer
Cohort Studies
Retrospective Studies
Incidence
Population
Odds Ratio
Databases
National Health Programs
Taiwan
Proportional Hazards Models
Logistic Models

Keywords

  • central serous chorioretinopathy
  • Helicobacter pylori
  • peptic ulcer
  • population-based cohort study

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Increased incidence of peptic ulcer disease in central serous chorioretinopathy patients : A population-based retrospective cohort study. / Chen, San Ni; Lian, Iebin; Chen, Yi Chiao; Ho, Jau Der.

In: Retina, Vol. 35, No. 2, 06.02.2015, p. 231-237.

Research output: Contribution to journalArticle

@article{79dfa21472a94ee29f3846a9db4ff076,
title = "Increased incidence of peptic ulcer disease in central serous chorioretinopathy patients: A population-based retrospective cohort study",
abstract = "PURPOSE:: To investigate peptic ulcer disease and other possible risk factors in patients with central serous chorioretinopathy (CSR) using a population-based database. METHODS:: In this population-based retrospective cohort study, longitudinal data from the Taiwan National Health Insurance Research Database were analyzed. The study cohort comprised 835 patients with CSR and the control cohort comprised 4175 patients without CSR from January 2000 to December 2009. Conditional logistic regression was applied to examine the association of peptic ulcer disease and other possible risk factors for CSR, and stratified Cox regression models were applied to examine whether patients with CSR have an increased chance of peptic ulcer disease and hypertension development. RESULTS:: The identifiable risk factors for CSR included peptic ulcer disease (adjusted odd ratio: 1.39, P = 0.001) and higher monthly income (adjusted odd ratio: 1.30, P = 0.006). Patients with CSR also had a significantly higher chance of developing peptic ulcer disease after the diagnosis of CSR (adjusted odd ratio: 1.43, P = 0.009). CONCLUSION:: Peptic ulcer disease and higher monthly income are independent risk factors for CSR. Whereas, patients with CSR also had increased risk for peptic ulcer development.",
keywords = "central serous chorioretinopathy, Helicobacter pylori, peptic ulcer, population-based cohort study",
author = "Chen, {San Ni} and Iebin Lian and Chen, {Yi Chiao} and Ho, {Jau Der}",
year = "2015",
month = "2",
day = "6",
doi = "10.1097/IAE.0000000000000278",
language = "English",
volume = "35",
pages = "231--237",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Increased incidence of peptic ulcer disease in central serous chorioretinopathy patients

T2 - A population-based retrospective cohort study

AU - Chen, San Ni

AU - Lian, Iebin

AU - Chen, Yi Chiao

AU - Ho, Jau Der

PY - 2015/2/6

Y1 - 2015/2/6

N2 - PURPOSE:: To investigate peptic ulcer disease and other possible risk factors in patients with central serous chorioretinopathy (CSR) using a population-based database. METHODS:: In this population-based retrospective cohort study, longitudinal data from the Taiwan National Health Insurance Research Database were analyzed. The study cohort comprised 835 patients with CSR and the control cohort comprised 4175 patients without CSR from January 2000 to December 2009. Conditional logistic regression was applied to examine the association of peptic ulcer disease and other possible risk factors for CSR, and stratified Cox regression models were applied to examine whether patients with CSR have an increased chance of peptic ulcer disease and hypertension development. RESULTS:: The identifiable risk factors for CSR included peptic ulcer disease (adjusted odd ratio: 1.39, P = 0.001) and higher monthly income (adjusted odd ratio: 1.30, P = 0.006). Patients with CSR also had a significantly higher chance of developing peptic ulcer disease after the diagnosis of CSR (adjusted odd ratio: 1.43, P = 0.009). CONCLUSION:: Peptic ulcer disease and higher monthly income are independent risk factors for CSR. Whereas, patients with CSR also had increased risk for peptic ulcer development.

AB - PURPOSE:: To investigate peptic ulcer disease and other possible risk factors in patients with central serous chorioretinopathy (CSR) using a population-based database. METHODS:: In this population-based retrospective cohort study, longitudinal data from the Taiwan National Health Insurance Research Database were analyzed. The study cohort comprised 835 patients with CSR and the control cohort comprised 4175 patients without CSR from January 2000 to December 2009. Conditional logistic regression was applied to examine the association of peptic ulcer disease and other possible risk factors for CSR, and stratified Cox regression models were applied to examine whether patients with CSR have an increased chance of peptic ulcer disease and hypertension development. RESULTS:: The identifiable risk factors for CSR included peptic ulcer disease (adjusted odd ratio: 1.39, P = 0.001) and higher monthly income (adjusted odd ratio: 1.30, P = 0.006). Patients with CSR also had a significantly higher chance of developing peptic ulcer disease after the diagnosis of CSR (adjusted odd ratio: 1.43, P = 0.009). CONCLUSION:: Peptic ulcer disease and higher monthly income are independent risk factors for CSR. Whereas, patients with CSR also had increased risk for peptic ulcer development.

KW - central serous chorioretinopathy

KW - Helicobacter pylori

KW - peptic ulcer

KW - population-based cohort study

UR - http://www.scopus.com/inward/record.url?scp=84922399462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922399462&partnerID=8YFLogxK

U2 - 10.1097/IAE.0000000000000278

DO - 10.1097/IAE.0000000000000278

M3 - Article

C2 - 25099218

AN - SCOPUS:84922399462

VL - 35

SP - 231

EP - 237

JO - Retina

JF - Retina

SN - 0275-004X

IS - 2

ER -