Increased frequency of genital human papillomavirus infection in human immunodeficiency virus-seropositive Taiwanese women

Mei Jou Chen, Ming Yih Wu, Jehn Hsiahn Yang, Kuang Han Chao, Yu Shih Yang, Hong Nerng Ho

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and Purpose: Human papillomavirus (HPV) infection is associated with increased incidence and severity of HPV-related cervical dysplasia and cervical cancer in women with human immunodeficiency virus (HIV) infection. This study examined the incidence of genital HPV infection in HIV-infected Taiwanese women and its relationship with cervical neoplasia. Methods: This hospital-based, case-control study enrolled 31 consecutive HIV-eeropositive women and 124 age-matched women who were free from HIV infection. Polymerase chain reaction (PCR) was used to distinguish high-risk (types 16, 18, 31, 33, 52 and 58) and low-risk HPV (types 6 and 11). The occurrence of genital HPV infection was compared between women with and without HIV infection. In addition, CD4 lymphocyte counts were determined by flow cytometry and Papanicolaou test was done in women with HIV infection. Results: HPV and Papanicolaou test were done soon after the diagnosis of HIV infection. HIV seropositive women had a significantly greater high-risk HPV infection rate (48.4%; 15/31) than women without HIV infection (20.2%; 25/124; odds ratio, 3.71; p = 0.001). However, the prevalence of cervical intraepithelial neoplasia was similar between women with and without HIV infection. The CD4 lymphocyte counts in HIV-seropositive women were similar between those with and without genital HPV infection. Conclusions: The risk of genital HPV infection was significantly increased in HIV-infected women. Due to the association between high-risk HPV infection and the development of cervical dysplasia and cervical cancer, regular follow-up of Papanicolaou test is necessary in these women.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalJournal of the Formosan Medical Association
Volume104
Issue number1
Publication statusPublished - Dec 1 2005
Externally publishedYes

Fingerprint

Papillomaviridae
HIV Seropositivity
Cervical Intraepithelial Neoplasia
Papillomavirus Infections
Vagina
CD4 Lymphocyte Count
Taiwan
Uterine Cervical Neoplasms
Case-Control Studies
HIV
Virus Diseases
Papanicolaou Test
Uterine Cervical Dysplasia
Human papillomavirus 11
Human papillomavirus 6

Keywords

  • CD4 lymphocyte count
  • Cervical intraepithelial neoplasia
  • HIV
  • Papillomavirus, human

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Increased frequency of genital human papillomavirus infection in human immunodeficiency virus-seropositive Taiwanese women. / Chen, Mei Jou; Wu, Ming Yih; Yang, Jehn Hsiahn; Chao, Kuang Han; Yang, Yu Shih; Ho, Hong Nerng.

In: Journal of the Formosan Medical Association, Vol. 104, No. 1, 01.12.2005, p. 34-38.

Research output: Contribution to journalArticle

Chen, Mei Jou ; Wu, Ming Yih ; Yang, Jehn Hsiahn ; Chao, Kuang Han ; Yang, Yu Shih ; Ho, Hong Nerng. / Increased frequency of genital human papillomavirus infection in human immunodeficiency virus-seropositive Taiwanese women. In: Journal of the Formosan Medical Association. 2005 ; Vol. 104, No. 1. pp. 34-38.
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abstract = "Background and Purpose: Human papillomavirus (HPV) infection is associated with increased incidence and severity of HPV-related cervical dysplasia and cervical cancer in women with human immunodeficiency virus (HIV) infection. This study examined the incidence of genital HPV infection in HIV-infected Taiwanese women and its relationship with cervical neoplasia. Methods: This hospital-based, case-control study enrolled 31 consecutive HIV-eeropositive women and 124 age-matched women who were free from HIV infection. Polymerase chain reaction (PCR) was used to distinguish high-risk (types 16, 18, 31, 33, 52 and 58) and low-risk HPV (types 6 and 11). The occurrence of genital HPV infection was compared between women with and without HIV infection. In addition, CD4 lymphocyte counts were determined by flow cytometry and Papanicolaou test was done in women with HIV infection. Results: HPV and Papanicolaou test were done soon after the diagnosis of HIV infection. HIV seropositive women had a significantly greater high-risk HPV infection rate (48.4{\%}; 15/31) than women without HIV infection (20.2{\%}; 25/124; odds ratio, 3.71; p = 0.001). However, the prevalence of cervical intraepithelial neoplasia was similar between women with and without HIV infection. The CD4 lymphocyte counts in HIV-seropositive women were similar between those with and without genital HPV infection. Conclusions: The risk of genital HPV infection was significantly increased in HIV-infected women. Due to the association between high-risk HPV infection and the development of cervical dysplasia and cervical cancer, regular follow-up of Papanicolaou test is necessary in these women.",
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