Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata

Yuh Ming Hwu, Sheng Hsiang Li, Robert Kuo kuang Lee, Yu Hui Tsai, Tian-Shun Tsai, Shyr Yeu Lin

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Abstract

This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor α (PDGFR-α), and receptor β (PDGFR-β) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-α, or PDGFR-β between leiomyomata and the adjacent myometrial tissues.

Original languageEnglish
Pages (from-to)468-471
Number of pages4
JournalFertility and Sterility
Volume89
Issue number2
DOIs
Publication statusPublished - Feb 2008

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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