Increased expression of osteopontin is associated with long-term bee venom immunotherapy

Satoshi Konno, David B.K. Golden, John Schroeder, Robert G. Hamilton, Lawrence M. Lichtenstein, Shau Ku Huang

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Venom allergen immunotherapy (VIT) is proven to be highly effective for insect allergy, but the mechanisms and the biomarkers associated with clinical efficacy remain elusive. Objective: The aim of this study was to identify candidate biomarkers associated with successful VIT. Methods: Gene chip array and clustering analyses of PBMCs from subjects with or without VIT were performed. Results: From gene chip array and clustering analyses, an increased expression of osteopontin was found in patients who completed 5 to 6 years of VIT and discontinued therapy for 3 to 6 years (completed treatment group) compared with the untreated group. A significantly higher level of serum osteopontin was found in the completed treatment group compared with the untreated group (n = 16 in each group; P <. 001). Conclusion: The upregulation of osteopontin after VIT suggests a role of osteopontin as a candidate biomarker for VIT.

Original languageEnglish
Pages (from-to)1063-1067
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume115
Issue number5
DOIs
Publication statusPublished - Jan 1 2005
Externally publishedYes

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Keywords

  • Biomarker
  • Clustering
  • Gene chip microarray
  • Osteopontin
  • Venom immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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