Abstract

Enolase-α (ENO-1) is a key glycolytic enzyme that has been used as a diagnostic marker to identify human lung cancers. To investigate the role of ENO-1 in breast cancer diagnosis and therapy, the mRNA levels of ENO-1 in 244 tumor and normal paired tissue samples and 20 laser capture-microdissected cell clusters were examined by quantitative real-time PCR analysis. Increased ENO-1 mRNA expression was preferentially detected in estrogen receptor-positive (ER+) tumors (tumor/normal ratio >90fold) when compared to ER-negative (tumor/normal ratio >20-fold) tumor tissues. The data presented here demonstrate that those patients whose tumors highly expressed ENO-1 had a poor prognosis with greater tumor size (>2 cm, *P = .017), poor nodal status (N > 3, *P = .018), and a shorter disease-free interval (≤1 year, *P

Original languageEnglish
Pages (from-to)539-553
Number of pages15
JournalBreast Cancer Research and Treatment
Volume121
Issue number3
DOIs
Publication statusPublished - Jun 2010

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Phosphopyruvate Hydratase
Tamoxifen
Breast Neoplasms
Neoplasms
Messenger RNA
Estrogen Receptors
Real-Time Polymerase Chain Reaction
Lung Neoplasms
Lasers
Enzymes

Keywords

  • Breast cancer
  • Enolase-1
  • Estrogen receptor alpha
  • Nuclear factor kappa B
  • Tamoxifen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Increased expression of enolase α in human breast cancer confers tamoxifen resistance in human breast cancer cells. / Tu, Shih Hsin; Chang, Chih Chiang; Chen, Ching Shyang; Tam, Ka Wai; Wang, Ying Jan; Lee, Chia Hwa; Lin, Hsiao Wei; Cheng, Tzu Chun; Huang, Ching Shui; Chu, Jan Show; Shih, Neng Yao; Chen, Li Ching; Leu, Sy Jye; Ho, Yuan Soon; Wu, Chih Hsiung.

In: Breast Cancer Research and Treatment, Vol. 121, No. 3, 06.2010, p. 539-553.

Research output: Contribution to journalArticle

Tu, Shih Hsin ; Chang, Chih Chiang ; Chen, Ching Shyang ; Tam, Ka Wai ; Wang, Ying Jan ; Lee, Chia Hwa ; Lin, Hsiao Wei ; Cheng, Tzu Chun ; Huang, Ching Shui ; Chu, Jan Show ; Shih, Neng Yao ; Chen, Li Ching ; Leu, Sy Jye ; Ho, Yuan Soon ; Wu, Chih Hsiung. / Increased expression of enolase α in human breast cancer confers tamoxifen resistance in human breast cancer cells. In: Breast Cancer Research and Treatment. 2010 ; Vol. 121, No. 3. pp. 539-553.
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