Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

Jia Sin Yang, Mu Kuan Chen, Shun Fa Yang, Yu Chao Chang, Shih Chi Su, Hui Ling Chiou, Ming Hsien Chien, Chiao Wen Lin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p

Original languageEnglish
Pages (from-to)1367-1377
Number of pages11
JournalClinical Chemistry and Laboratory Medicine
Volume52
Issue number9
DOIs
Publication statusPublished - Sep 1 2014

Keywords

  • Carbonic anhydrase IX (CAIX)
  • Chewed areca nuts
  • Oral cancer
  • Oral submucous fibrosis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

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