Increased admission serum estradiol level is correlated with high mortality in patients with severe acute pancreatitis

Chih Wei Lu, Liang Chih Liu, Ya Ching Hsieh, Li Heng Yang, Ray Jade Chen, Chi Hsun Hsieh

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7 Citations (Scopus)


Background Sexual dimorphism in critical diseases has been documented. Severe acute pancreatitis is a disease with high mortality. We hypothesized that admission sex hormone levels may be used as an early predictor of outcome in these patients. Methods A prospective cohort of patients with severe acute pancreatitis admitted to the intensive care unit for at least 48 h were enrolled (n = 62). Serum levels of estradiol, progesterone, and testosterone were determined on admission. The association of sex hormone levels and various disease severity scoring systems with patient outcome was analyzed. Results There was no difference in overall mortality between the sexes. However, estradiol was significantly elevated in nonsurvivors (39 vs. 206 pg/mL, p

Original languageEnglish
Pages (from-to)374-381
Number of pages8
JournalJournal of Gastroenterology
Issue number3
Publication statusPublished - Mar 2013



  • Acute pancreatitis
  • Estradiol
  • Mortality

ASJC Scopus subject areas

  • Gastroenterology

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