Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease

Shao Ming Wang, Yi Chao Lee, Chiung Yuan Ko, Ming Derg Lai, Ding Yen Lin, Ping Chieh Pao, Jhih Ying Chi, Yu Wei Hsiao, Tsung Lin Liu, Ju Ming Wang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Reactive astrogliosis is a cellular manifestation of neuroinflammation and occurs in response to all forms and severities of the central nervous system (CNS)’s injury and disease. Both astroglial proliferation and antiapoptotic processes are aspects of astrogliosis. However, the underlying mechanism of this response remains poorly understood. In addition, little is known about why activated astrocytes are more resistant to stress and inflammation. CCAAT/enhancer binding protein delta (CEBPD) is a transcription factor found in activated astrocytes that surround β-amyloid plaques. In this study, we found that astrocytes activation was attenuated in the cortex and hippocampus of APPswe/PS1 E9 (AppTg)/Cebpd−/−mice. Furthermore, an increase in apoptotic astrocytes was observed in AppTg/Cebpd−/−mice, suggesting that CEBPD plays a functional role in enhancing the antiapoptotic ability of astrocytes. We found that Zinc Finger Protein 179 (ZNF179) was a CEBPD-regulated gene that played an antiapoptotic, but not proliferative, role in astrocytes. The transcriptions of the proapoptotic genes, insulin-like growth factor binding protein 3 (IGFBP3) and BCL2-interacting killer (BIK), were suppressed by ZNF179 via its interaction with the promyelocytic leukemia zinc finger (PLZF) protein in astrocytes. This study provides the first evidence that ZNF179, PLZF, IGFBP3, and BIK contributed to the novel CEBPD-induced antiapoptotic feature of astrocytes.

Original languageEnglish
Pages (from-to)370-382
Number of pages13
JournalMolecular Neurobiology
Volume51
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

CCAAT-Enhancer-Binding Protein-delta
Zinc Fingers
Astrocytes
Alzheimer Disease
Proteins
Insulin-Like Growth Factor Binding Protein 3
Nervous System Trauma
Aptitude
Amyloid Plaques
Nervous System Diseases
Genes
Hippocampus
Leukemia
Transcription Factors
Central Nervous System

Keywords

  • Alzheimer’s disease
  • Antiapoptosis
  • Astrocytes
  • CEBPD
  • ZNF179

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease. / Wang, Shao Ming; Lee, Yi Chao; Ko, Chiung Yuan; Lai, Ming Derg; Lin, Ding Yen; Pao, Ping Chieh; Chi, Jhih Ying; Hsiao, Yu Wei; Liu, Tsung Lin; Wang, Ju Ming.

In: Molecular Neurobiology, Vol. 51, No. 1, 2014, p. 370-382.

Research output: Contribution to journalArticle

Wang, Shao Ming ; Lee, Yi Chao ; Ko, Chiung Yuan ; Lai, Ming Derg ; Lin, Ding Yen ; Pao, Ping Chieh ; Chi, Jhih Ying ; Hsiao, Yu Wei ; Liu, Tsung Lin ; Wang, Ju Ming. / Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease. In: Molecular Neurobiology. 2014 ; Vol. 51, No. 1. pp. 370-382.
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AU - Lee, Yi Chao

AU - Ko, Chiung Yuan

AU - Lai, Ming Derg

AU - Lin, Ding Yen

AU - Pao, Ping Chieh

AU - Chi, Jhih Ying

AU - Hsiao, Yu Wei

AU - Liu, Tsung Lin

AU - Wang, Ju Ming

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AB - Reactive astrogliosis is a cellular manifestation of neuroinflammation and occurs in response to all forms and severities of the central nervous system (CNS)’s injury and disease. Both astroglial proliferation and antiapoptotic processes are aspects of astrogliosis. However, the underlying mechanism of this response remains poorly understood. In addition, little is known about why activated astrocytes are more resistant to stress and inflammation. CCAAT/enhancer binding protein delta (CEBPD) is a transcription factor found in activated astrocytes that surround β-amyloid plaques. In this study, we found that astrocytes activation was attenuated in the cortex and hippocampus of APPswe/PS1 E9 (AppTg)/Cebpd−/−mice. Furthermore, an increase in apoptotic astrocytes was observed in AppTg/Cebpd−/−mice, suggesting that CEBPD plays a functional role in enhancing the antiapoptotic ability of astrocytes. We found that Zinc Finger Protein 179 (ZNF179) was a CEBPD-regulated gene that played an antiapoptotic, but not proliferative, role in astrocytes. The transcriptions of the proapoptotic genes, insulin-like growth factor binding protein 3 (IGFBP3) and BCL2-interacting killer (BIK), were suppressed by ZNF179 via its interaction with the promyelocytic leukemia zinc finger (PLZF) protein in astrocytes. This study provides the first evidence that ZNF179, PLZF, IGFBP3, and BIK contributed to the novel CEBPD-induced antiapoptotic feature of astrocytes.

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