Increase of β-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats

H. S. Niu, F. L. Hsu, I. M. Liu, J. T. Cheng

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We employed streptozotocin-induced diabetic rats (STZ-diabetic rats) as type 1 diabetes-like animal models to investigate the mechanism(s) of antihyperglycemic action produced by syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae). Bolus intravenous (i.v.) injection of syringin dose-dependently decreased the plasma glucose of STZ-diabetic rats in 30 minutes in a way parallel to the increase of plasma β-endorphin-like immunoreactivity (BER). Syringin enhanced BER release from the isolated adrenal medulla of STZ-diabetic rats in a concentration-dependent manner from 0.001 to 10 μmol/l. Bilateral adrenalectomy in STZ-diabetic rats eliminated the activities of syringin (1 mg/kg, i.v.) including the plasma glucose-lowering effect and the plasma BER-elevating effect. Also, syringin failed to lower plasma glucose in the presence of μ-opioid receptor antagonists and/or in the μ-opioid receptor knockout diabetic mice. In conclusion, the obtained results suggest that syringin can enhance the secretion of β-endorphin from adrenal medulla to stimulate peripheral μ-opioid receptors resulting in a decrease of plasma glucose in diabetic rats lacking insulin.

Original languageEnglish
Pages (from-to)894-898
Number of pages5
JournalHormone and Metabolic Research
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Eleutherococcus
Endorphins
Hypoglycemic Agents
Rats
Streptozocin
Plasmas
Glucose
Adrenal Medulla
Opioid Receptors
Araliaceae
Rhizome
Narcotic Antagonists
Adrenalectomy
Medical problems
Type 1 Diabetes Mellitus
Knockout Mice
Intravenous Injections
syringin
Animals
Animal Models

Keywords

  • β-endorphin
  • μ-opioid receptors
  • Streptozotocin-induced diabetic rats
  • Syringin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Increase of β-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats. / Niu, H. S.; Hsu, F. L.; Liu, I. M.; Cheng, J. T.

In: Hormone and Metabolic Research, Vol. 39, No. 12, 12.2007, p. 894-898.

Research output: Contribution to journalArticle

@article{774fccf6206a4719ba50ebe68291691b,
title = "Increase of β-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats",
abstract = "We employed streptozotocin-induced diabetic rats (STZ-diabetic rats) as type 1 diabetes-like animal models to investigate the mechanism(s) of antihyperglycemic action produced by syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae). Bolus intravenous (i.v.) injection of syringin dose-dependently decreased the plasma glucose of STZ-diabetic rats in 30 minutes in a way parallel to the increase of plasma β-endorphin-like immunoreactivity (BER). Syringin enhanced BER release from the isolated adrenal medulla of STZ-diabetic rats in a concentration-dependent manner from 0.001 to 10 μmol/l. Bilateral adrenalectomy in STZ-diabetic rats eliminated the activities of syringin (1 mg/kg, i.v.) including the plasma glucose-lowering effect and the plasma BER-elevating effect. Also, syringin failed to lower plasma glucose in the presence of μ-opioid receptor antagonists and/or in the μ-opioid receptor knockout diabetic mice. In conclusion, the obtained results suggest that syringin can enhance the secretion of β-endorphin from adrenal medulla to stimulate peripheral μ-opioid receptors resulting in a decrease of plasma glucose in diabetic rats lacking insulin.",
keywords = "β-endorphin, μ-opioid receptors, Streptozotocin-induced diabetic rats, Syringin",
author = "Niu, {H. S.} and Hsu, {F. L.} and Liu, {I. M.} and Cheng, {J. T.}",
year = "2007",
month = "12",
doi = "10.1055/s-2007-993154",
language = "English",
volume = "39",
pages = "894--898",
journal = "Hormone and Metabolic Research",
issn = "0018-5043",
publisher = "Georg Thieme Verlag",
number = "12",

}

TY - JOUR

T1 - Increase of β-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats

AU - Niu, H. S.

AU - Hsu, F. L.

AU - Liu, I. M.

AU - Cheng, J. T.

PY - 2007/12

Y1 - 2007/12

N2 - We employed streptozotocin-induced diabetic rats (STZ-diabetic rats) as type 1 diabetes-like animal models to investigate the mechanism(s) of antihyperglycemic action produced by syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae). Bolus intravenous (i.v.) injection of syringin dose-dependently decreased the plasma glucose of STZ-diabetic rats in 30 minutes in a way parallel to the increase of plasma β-endorphin-like immunoreactivity (BER). Syringin enhanced BER release from the isolated adrenal medulla of STZ-diabetic rats in a concentration-dependent manner from 0.001 to 10 μmol/l. Bilateral adrenalectomy in STZ-diabetic rats eliminated the activities of syringin (1 mg/kg, i.v.) including the plasma glucose-lowering effect and the plasma BER-elevating effect. Also, syringin failed to lower plasma glucose in the presence of μ-opioid receptor antagonists and/or in the μ-opioid receptor knockout diabetic mice. In conclusion, the obtained results suggest that syringin can enhance the secretion of β-endorphin from adrenal medulla to stimulate peripheral μ-opioid receptors resulting in a decrease of plasma glucose in diabetic rats lacking insulin.

AB - We employed streptozotocin-induced diabetic rats (STZ-diabetic rats) as type 1 diabetes-like animal models to investigate the mechanism(s) of antihyperglycemic action produced by syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae). Bolus intravenous (i.v.) injection of syringin dose-dependently decreased the plasma glucose of STZ-diabetic rats in 30 minutes in a way parallel to the increase of plasma β-endorphin-like immunoreactivity (BER). Syringin enhanced BER release from the isolated adrenal medulla of STZ-diabetic rats in a concentration-dependent manner from 0.001 to 10 μmol/l. Bilateral adrenalectomy in STZ-diabetic rats eliminated the activities of syringin (1 mg/kg, i.v.) including the plasma glucose-lowering effect and the plasma BER-elevating effect. Also, syringin failed to lower plasma glucose in the presence of μ-opioid receptor antagonists and/or in the μ-opioid receptor knockout diabetic mice. In conclusion, the obtained results suggest that syringin can enhance the secretion of β-endorphin from adrenal medulla to stimulate peripheral μ-opioid receptors resulting in a decrease of plasma glucose in diabetic rats lacking insulin.

KW - β-endorphin

KW - μ-opioid receptors

KW - Streptozotocin-induced diabetic rats

KW - Syringin

UR - http://www.scopus.com/inward/record.url?scp=38149006376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149006376&partnerID=8YFLogxK

U2 - 10.1055/s-2007-993154

DO - 10.1055/s-2007-993154

M3 - Article

VL - 39

SP - 894

EP - 898

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

SN - 0018-5043

IS - 12

ER -