Increase in the production of interleukin-10 early after implantation is related to the success of pregnancy

Ming Yih Wu, Hsin Fu Chen, Shee Uan Chen, Kuang Han Chao, Yu Shih Yang, Hong Nerng Ho

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Problem: To study the correlation of interleukin (IL)-10, IL-11 leukemia inhibitory factor (LIF), placental growth factor (P1GF), and transforming growth factor (TGF)-β and outcome of human pregnancy. Method of study: We prospectively measured the serum levels of these cytokines in patients undergoing in vitro fertilization (IVF) programs. A total of 60 women (non-pregnant, n = 27; early abortions, n = 12; normal pregnancies, n = 21) were enrolled. Results: There was no difference in the cytokines studied on D0 and D14 among the three groups of women. The increase in P1GF from D0 to D14 after human chorionic gonadotropin (hCG) injection was greater in pregnant women than in non-pregnant women; however, the difference did not reach significance (P = 0.068). The increase in IL-10 production from D14 and D21 was significant in women with successful pregnancies compared to women in the abortion group. Conclusions: This increase in IL-10 may be important in sustaining a normal pregnancy early after implantation.

Original languageEnglish
Pages (from-to)386-392
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume46
Issue number6
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

Fingerprint

Interleukin-11
Pregnancy Proteins
Leukemia Inhibitory Factor
Transforming Growth Factor beta1
Growth Inhibitors
Lymphokines
Fertilization in Vitro
Pregnancy Outcome
Transforming Growth Factor beta
Interleukin-10
Interleukin-6
Prospective Studies
Pregnancy
Pregnant Women
Cytokines
Chorionic Gonadotropin
Intercellular Signaling Peptides and Proteins
Injections
Serum

Keywords

  • Abortion
  • Interleukin (IL)-10
  • Leukemia inhibitory factor (LIF)
  • Placental growth factor (P1GF)
  • Transforming growth factor (TGF)-β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Increase in the production of interleukin-10 early after implantation is related to the success of pregnancy. / Wu, Ming Yih; Chen, Hsin Fu; Chen, Shee Uan; Chao, Kuang Han; Yang, Yu Shih; Ho, Hong Nerng.

In: American Journal of Reproductive Immunology, Vol. 46, No. 6, 01.01.2001, p. 386-392.

Research output: Contribution to journalArticle

Wu, Ming Yih ; Chen, Hsin Fu ; Chen, Shee Uan ; Chao, Kuang Han ; Yang, Yu Shih ; Ho, Hong Nerng. / Increase in the production of interleukin-10 early after implantation is related to the success of pregnancy. In: American Journal of Reproductive Immunology. 2001 ; Vol. 46, No. 6. pp. 386-392.
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