Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis

Ming Yih Wu, Jehn Hsiahn Yang, Kuang Han Chao, Jiann Loung Hwang, Yu Shih Yang, Hong Nerng Ho

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: Malfunction of peritoneal natural killer cells (NK) may result in endometriosis. The present study was designed to determine whether the decrease in NK cytotoxicity occurs at early and advanced stages of endometriosis and is due to the increase in the NK inhibition receptors. Design: A case control study. Setting: A tertiary-care infertility center. Patient(s): A total of 44 women (controls, n = 11; women with early-stage endometriosis, n = 11; and women with advanced-stage endometriosis, n = 22) were included in this study. Intervention(s): Laparoscopic examination. Main Outcome Measure(s): NK cytotoxicity was determined by assay of 51Cr release against K562 cells, and the expression of killer cell inhibitory receptors (KIR, including NKB1, GL183, and EB6) in NK cells was examined by flow cytometry. Result(s): Women with endometriosis showed a decrease in peritoneal NK cytotoxicities against K562 at early and advanced stages of endometriosis. The expression of KIR (NKB1 and EB6) was significantly elevated in the peritoneal NK cells of women with advanced-stage endometriosis compared with controls. KIR (NKB1) was also significantly increased in peritoneal NK cells of women with advanced-stage endometriosis, compared with those of women with early-stage endometriosis. Conclusion(s): The results of this study suggest that the decrease in peritoneal NK cytotoxicities against K562 is observed and that this disease may be partially due to the increased expression of KIR on these NK cells. Copyright (C) 2000 American Society for Reproductive Medicine.

Original languageEnglish
Pages (from-to)1187-1191
Number of pages5
JournalFertility and Sterility
Volume74
Issue number6
DOIs
Publication statusPublished - Dec 28 2000
Externally publishedYes

Fingerprint

Immunologic Cytotoxicity
Immunologic Receptors
KIR Receptors
Ascitic Fluid
Endometriosis
Natural Killer Cells
Laparoscopy
Case-Control Studies
Reference Values
Cell Line
Natural Killer Cell Receptors
K562 Cells
Tertiary Care Centers
Infertility

Keywords

  • Cytotoxicity
  • Endometriosis
  • Killer cell inhibitory receptors (KIR)
  • Peritoneal fluid

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis. / Wu, Ming Yih; Yang, Jehn Hsiahn; Chao, Kuang Han; Hwang, Jiann Loung; Yang, Yu Shih; Ho, Hong Nerng.

In: Fertility and Sterility, Vol. 74, No. 6, 28.12.2000, p. 1187-1191.

Research output: Contribution to journalArticle

Wu, Ming Yih ; Yang, Jehn Hsiahn ; Chao, Kuang Han ; Hwang, Jiann Loung ; Yang, Yu Shih ; Ho, Hong Nerng. / Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis. In: Fertility and Sterility. 2000 ; Vol. 74, No. 6. pp. 1187-1191.
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AU - Yang, Yu Shih

AU - Ho, Hong Nerng

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N2 - Objective: Malfunction of peritoneal natural killer cells (NK) may result in endometriosis. The present study was designed to determine whether the decrease in NK cytotoxicity occurs at early and advanced stages of endometriosis and is due to the increase in the NK inhibition receptors. Design: A case control study. Setting: A tertiary-care infertility center. Patient(s): A total of 44 women (controls, n = 11; women with early-stage endometriosis, n = 11; and women with advanced-stage endometriosis, n = 22) were included in this study. Intervention(s): Laparoscopic examination. Main Outcome Measure(s): NK cytotoxicity was determined by assay of 51Cr release against K562 cells, and the expression of killer cell inhibitory receptors (KIR, including NKB1, GL183, and EB6) in NK cells was examined by flow cytometry. Result(s): Women with endometriosis showed a decrease in peritoneal NK cytotoxicities against K562 at early and advanced stages of endometriosis. The expression of KIR (NKB1 and EB6) was significantly elevated in the peritoneal NK cells of women with advanced-stage endometriosis compared with controls. KIR (NKB1) was also significantly increased in peritoneal NK cells of women with advanced-stage endometriosis, compared with those of women with early-stage endometriosis. Conclusion(s): The results of this study suggest that the decrease in peritoneal NK cytotoxicities against K562 is observed and that this disease may be partially due to the increased expression of KIR on these NK cells. Copyright (C) 2000 American Society for Reproductive Medicine.

AB - Objective: Malfunction of peritoneal natural killer cells (NK) may result in endometriosis. The present study was designed to determine whether the decrease in NK cytotoxicity occurs at early and advanced stages of endometriosis and is due to the increase in the NK inhibition receptors. Design: A case control study. Setting: A tertiary-care infertility center. Patient(s): A total of 44 women (controls, n = 11; women with early-stage endometriosis, n = 11; and women with advanced-stage endometriosis, n = 22) were included in this study. Intervention(s): Laparoscopic examination. Main Outcome Measure(s): NK cytotoxicity was determined by assay of 51Cr release against K562 cells, and the expression of killer cell inhibitory receptors (KIR, including NKB1, GL183, and EB6) in NK cells was examined by flow cytometry. Result(s): Women with endometriosis showed a decrease in peritoneal NK cytotoxicities against K562 at early and advanced stages of endometriosis. The expression of KIR (NKB1 and EB6) was significantly elevated in the peritoneal NK cells of women with advanced-stage endometriosis compared with controls. KIR (NKB1) was also significantly increased in peritoneal NK cells of women with advanced-stage endometriosis, compared with those of women with early-stage endometriosis. Conclusion(s): The results of this study suggest that the decrease in peritoneal NK cytotoxicities against K562 is observed and that this disease may be partially due to the increased expression of KIR on these NK cells. Copyright (C) 2000 American Society for Reproductive Medicine.

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