Increase in 12-lipoxygenase activity in platelets of spontaneously hypertensive rats

Wen Chang Chang, Gin Wen Su

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

12-Lipoxygenase activity in platelets of spontaneously hypertensive rats was investigated. Enzyme activity was measured in the absence and the presence of reduced glutathione. In both assay conditions, 12-lipoxygenase activity in platelets of spontaneously hypertensive rats was significantly higher than that in platelets of normotensive rats. Since 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), a 12-lipoxygenase product of arachidonic acid in platelets, has been reported to be a potent chemoattractant for aortic smooth muscle cells, increase in biosynthesis of 12-HETE in platelets of spontaneously hypertensive rats might contribute to the explanation of pathogenesis of vascular disorder commonly found in hypertension patients.

Original languageEnglish
Pages (from-to)642-648
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume127
Issue number2
DOIs
Publication statusPublished - Mar 15 1985
Externally publishedYes

Fingerprint

Arachidonate 12-Lipoxygenase
Inbred SHR Rats
Platelets
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Rats
Blood Platelets
Biosynthesis
Chemotactic Factors
Enzyme activity
Arachidonic Acid
Smooth Muscle Myocytes
Glutathione
Blood Vessels
Muscle
Assays
Cells
Hypertension
Acids
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Increase in 12-lipoxygenase activity in platelets of spontaneously hypertensive rats. / Chang, Wen Chang; Su, Gin Wen.

In: Biochemical and Biophysical Research Communications, Vol. 127, No. 2, 15.03.1985, p. 642-648.

Research output: Contribution to journalArticle

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