@article{2d310811c86c44b88a00dc5d4a26edb1,
title = "Incidental congestive heart failure in patients with aldosterone-producing adenomas",
abstract = "Background-—Previous studies show that patients with primary aldosteronism are associated with higher risk of congestive heart failure (CHF). However, the effect of target treatment to the incidental CHF has not been elucidated. We aimed to investigate the risk of new-onset CHF in patients with aldosterone-producing adenomas (APAs) and explore the effect of adrenalectomy on new onset of CHF. Methods and Results-—From 1997 to 2009, 688 APA were identified and matched with essential hypertension controls. The risks of developing incidental CHF (hazard ratio, 0.49; 95% CI, 0.31–0.75; P=0.001) and mortality (hazard ratio, 0.29; 95% CI, 0.20–0.44; P<0.001) were significantly lower in the APA group after targeted treatment. A total of 605 patients with APAs who underwent adrenalectomy lowered the risks of CHF (subdistribution hazard ratio, 0.55; 95% CI, 0.34–0.90; P=0.017) and mortality (adjusted hazard ratio, 0.27; 95% CI, 0.16–0.44; P<0.001) compared with essential hypertension controls. Conclusions-—In conclusion, for patients with APAs, adrenalectomy can be associated with lower risk of incidental CHF and allcause mortality in a long-term follow-up.",
author = "{TAIPAI Study Group} and Huang, {Wei Chieh} and Chen, {Ying Ying} and Lin, {Yen Hung} and Likwang Chen and Lin, {Po Chih} and Lin, {Yu Feng} and Liu, {Yu Chun} and Wu, {Che Hsiung} and Chueh, {Jeff S.} and Chu, {Tzong Shinn} and Wu, {Kwan Dun} and Huang, {Chun Yao} and Wu, {Vin Cent}",
note = "Funding Information: Role of the sponsors: Some of the authors are employed by 2 organizations financially supporting the study: National Taiwan University Hospital and National Health Research Institutes. The other funding organization, National Science Council, neither played a role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; nor in the preparation, review, and approval of the manuscript. We thank Mr Eric B. Chueh for English editing of the manuscript. Wei Chieh Huang drafted the manuscript and collected data. Chun-Yao Huang and Vin-Cent Wu provided the original conception and design of the study, modified the statistical models critically, and provided technical and statistical support during the analyses. All the authors interpreted and had full access to the data, revised the manuscript critically, and approved the final article. This work was supported by a grant from Taipei Medical University (grant number, 105-TMU-NTUST-105-03) and Ministry of Science and Technology (MOST) of the Republic of China (Taiwan) (grant number, MOST 106-2321-B-182-002). Funding Information: This work was supported by a grant from Taipei Medical University (grant number, 105-TMU-NTUST-105-03) and Ministry of Science and Technology (MOST) of the Republic of China (Taiwan) (grant number, MOST 106-2321-B-182-002). Publisher Copyright: {\textcopyright} 2019 The Authors.",
year = "2019",
month = dec,
day = "17",
doi = "10.1161/JAHA.119.012410",
language = "English",
volume = "8",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "24",
}