TY - JOUR
T1 - Incidences of hypothyroidism associated with surgical procedures for thyroid disorders
T2 - A nationwide population-based study
AU - Tsai, Shin Han
AU - Chien, Shuo Chen
AU - Nguyen, Phung Anh
AU - Chien, Po Han
AU - Ma, Hon Ping
AU - Asdary, Rahma Novita
AU - Wang, Yao Chin
AU - Humayun, Ayesha
AU - Huang, Chen Ling
AU - Iqbal, Usman
AU - Jian, Wen Shan
N1 - Funding Information:
This research was supported by Taipei Medical University – Shuang-Ho Hospital, Ministry of Health and Welfare Project
Funding Information:
1 Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan, 2 Emergency Department, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan, 3 Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, 4 International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan, 5 Department and Graduate Institute of Business Administration, National Taiwan University, Taipei, Taiwan, 6 Master Program in Global Health and Development, PhD Program in Global Health and Health Security, College of Public Health, Taipei Medical University, Taipei, Taiwan, 7 Department of Emergency, Min-Sheng General Hospital, Taoyuan, Taiwan, 8 Department of Public Health and Community Medicine, Shaikh Khalifa Bin Zayed Al-Nahyan Medical College, Shaikh Zayed Medical Complex, Lahore, Pakistan, 9 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan, 10 School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
Funding Information:
This research was supported by Taipei Medical University - Shuang-Ho Hospital, Ministry of Health and Welfare Project number 105TMU-SHH-11, YUAN's Hospital project number 107YGH-TMU-10, and Ministry of Science of Technology project number MOST107-2218-E-038-004-MY2.*%blankline%*
Publisher Copyright:
Copyright © 2019 Tsai, Chien, Nguyen, Chien, Ma, Asdary, Wang, Humayun, Huang, Iqbal and Jian.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background and Aim: Limited information available about different types of thyroid surgeries with risk for postoperative hypothyroidism. This study aimed to investigate the risk of developing early and late-onset postoperative hypothyroidism in patients with thyroid disorders. Methods: We used a large cohort data from the Taiwan National Health Insurance Research Data Base (NHIRDB) and identified 9,693 (9, 348) patients from January 1998 to December 2010, admitted for thyroid disorder surgeries. We used the surgical procedures time as the index date. Our observational retrospective cohort study excluded the subjects diagnosed with hypoparathyroidism and hypothyroidism before any surgeries. We analyzed the data using the Cox regression model to calculate the hazard ratio. Result: Postoperative hypothyroidism associated with bilateral-total (HR, 4.27; 95% CI, 3.32-5.50), one-side total and another subtotal (HR, 3.16; 95% CI, 2.59-3.86), bilateralsubtotal (HR, 1.65; 95% CI, 1.37-1.98), and unilateral-total (HR, 1.17; 95% CI, 0.95-1.44) surgical procedures. The time intervals for thyroid disorders were 320 cases developed postoperative hypoparathyroidism in eight weeks, 480 cases the second month, and 1000 cases in the first year after surgery. Conclusion: Findings suggest that thyroidectomy was associated with transient postoperative hypothyroidism in thyroid disorder patients. The bilateral-total surgical procedure was strongly associated with temporary postoperative hypothyroidism.
AB - Background and Aim: Limited information available about different types of thyroid surgeries with risk for postoperative hypothyroidism. This study aimed to investigate the risk of developing early and late-onset postoperative hypothyroidism in patients with thyroid disorders. Methods: We used a large cohort data from the Taiwan National Health Insurance Research Data Base (NHIRDB) and identified 9,693 (9, 348) patients from January 1998 to December 2010, admitted for thyroid disorder surgeries. We used the surgical procedures time as the index date. Our observational retrospective cohort study excluded the subjects diagnosed with hypoparathyroidism and hypothyroidism before any surgeries. We analyzed the data using the Cox regression model to calculate the hazard ratio. Result: Postoperative hypothyroidism associated with bilateral-total (HR, 4.27; 95% CI, 3.32-5.50), one-side total and another subtotal (HR, 3.16; 95% CI, 2.59-3.86), bilateralsubtotal (HR, 1.65; 95% CI, 1.37-1.98), and unilateral-total (HR, 1.17; 95% CI, 0.95-1.44) surgical procedures. The time intervals for thyroid disorders were 320 cases developed postoperative hypoparathyroidism in eight weeks, 480 cases the second month, and 1000 cases in the first year after surgery. Conclusion: Findings suggest that thyroidectomy was associated with transient postoperative hypothyroidism in thyroid disorder patients. The bilateral-total surgical procedure was strongly associated with temporary postoperative hypothyroidism.
KW - BigData analytics
KW - Hormones
KW - Postoperative hypothyroidism
KW - Surgeons experience
KW - Thyroid disorders
KW - Thyroid surgeries
KW - Transient hypothyroidism
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U2 - 10.3389/fphar.2019.01378
DO - 10.3389/fphar.2019.01378
M3 - Article
AN - SCOPUS:85077198447
VL - 10
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
SN - 1663-9812
M1 - 1378
ER -