Incidence, risk factor, and prognosis of end-stage renal disease after heart transplantation in Chinese recipients

Jeng Wei Chen, Cheng Hsin Lin, Ron Bin Hsu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Purpose: End-stage renal disease (ESRD) is an important complication arising after heart transplantation. At least 3-10% of recipients reach ESRD within 10 years after transplant. The incidence of ESRD in Chinese recipients has not been reported. Here we sought to assess the incidence, prognosis, and risk factors for ESRD in Chinese recipients. Methods: We conducted a retrospective analysis of 248 heart recipients who survived >1 year from 1998 through 2007. ESRD was defined as the requirement of maintenance dialysis. Results: Renal dysfunction was present in 20 patients (8%) prior to transplant. With a follow-up duration of 5.8±3.9 years, 30 patients developed ESRD. The cumulative incidence of ESRD after heart transplantation was 2.1%±0.9%, 6.5%±1.8%, 16.8%±3.3%, and 36.5%±9.5% at 2, 5, 10, and 15 years after transplant, respectively. Median onset of ESRD was 6.9 years after transplant. Actuarial survival after dialysis was 74.8%±8.3%, 66.6%±9.2%, and 43.6%±12.6% at 1, 2, and 5 years, respectively. Independent risk factors for ESRD included pretransplant serum creatinine (hazard ratio, 1.84; p=0.001), presence of diabetes prior to transplant (hazard ratio, 2.51; p=0.017), and old age at transplant (hazard ratio, 1.05; p=0.008). Conclusion: There was a high incidence of ESRD in Chinese heart recipients. Patients with ESRD had poor prognosis after dialysis.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume113
Issue number1
DOIs
Publication statusPublished - Jan 2014
Externally publishedYes

Fingerprint

Heart Transplantation
Chronic Kidney Failure
Incidence
Transplants
Dialysis
Creatinine
Maintenance
Kidney
Survival

Keywords

  • Asian Continental Ancestry Group
  • Chronic
  • Heart transplantation
  • Kidney failure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{9a76b2aecc9a434dacb46c3a227e82f4,
title = "Incidence, risk factor, and prognosis of end-stage renal disease after heart transplantation in Chinese recipients",
abstract = "Background/Purpose: End-stage renal disease (ESRD) is an important complication arising after heart transplantation. At least 3-10{\%} of recipients reach ESRD within 10 years after transplant. The incidence of ESRD in Chinese recipients has not been reported. Here we sought to assess the incidence, prognosis, and risk factors for ESRD in Chinese recipients. Methods: We conducted a retrospective analysis of 248 heart recipients who survived >1 year from 1998 through 2007. ESRD was defined as the requirement of maintenance dialysis. Results: Renal dysfunction was present in 20 patients (8{\%}) prior to transplant. With a follow-up duration of 5.8±3.9 years, 30 patients developed ESRD. The cumulative incidence of ESRD after heart transplantation was 2.1{\%}±0.9{\%}, 6.5{\%}±1.8{\%}, 16.8{\%}±3.3{\%}, and 36.5{\%}±9.5{\%} at 2, 5, 10, and 15 years after transplant, respectively. Median onset of ESRD was 6.9 years after transplant. Actuarial survival after dialysis was 74.8{\%}±8.3{\%}, 66.6{\%}±9.2{\%}, and 43.6{\%}±12.6{\%} at 1, 2, and 5 years, respectively. Independent risk factors for ESRD included pretransplant serum creatinine (hazard ratio, 1.84; p=0.001), presence of diabetes prior to transplant (hazard ratio, 2.51; p=0.017), and old age at transplant (hazard ratio, 1.05; p=0.008). Conclusion: There was a high incidence of ESRD in Chinese heart recipients. Patients with ESRD had poor prognosis after dialysis.",
keywords = "Asian Continental Ancestry Group, Chronic, Heart transplantation, Kidney failure",
author = "Chen, {Jeng Wei} and Lin, {Cheng Hsin} and Hsu, {Ron Bin}",
year = "2014",
month = "1",
doi = "10.1016/j.jfma.2012.04.012",
language = "English",
volume = "113",
pages = "11--16",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Incidence, risk factor, and prognosis of end-stage renal disease after heart transplantation in Chinese recipients

AU - Chen, Jeng Wei

AU - Lin, Cheng Hsin

AU - Hsu, Ron Bin

PY - 2014/1

Y1 - 2014/1

N2 - Background/Purpose: End-stage renal disease (ESRD) is an important complication arising after heart transplantation. At least 3-10% of recipients reach ESRD within 10 years after transplant. The incidence of ESRD in Chinese recipients has not been reported. Here we sought to assess the incidence, prognosis, and risk factors for ESRD in Chinese recipients. Methods: We conducted a retrospective analysis of 248 heart recipients who survived >1 year from 1998 through 2007. ESRD was defined as the requirement of maintenance dialysis. Results: Renal dysfunction was present in 20 patients (8%) prior to transplant. With a follow-up duration of 5.8±3.9 years, 30 patients developed ESRD. The cumulative incidence of ESRD after heart transplantation was 2.1%±0.9%, 6.5%±1.8%, 16.8%±3.3%, and 36.5%±9.5% at 2, 5, 10, and 15 years after transplant, respectively. Median onset of ESRD was 6.9 years after transplant. Actuarial survival after dialysis was 74.8%±8.3%, 66.6%±9.2%, and 43.6%±12.6% at 1, 2, and 5 years, respectively. Independent risk factors for ESRD included pretransplant serum creatinine (hazard ratio, 1.84; p=0.001), presence of diabetes prior to transplant (hazard ratio, 2.51; p=0.017), and old age at transplant (hazard ratio, 1.05; p=0.008). Conclusion: There was a high incidence of ESRD in Chinese heart recipients. Patients with ESRD had poor prognosis after dialysis.

AB - Background/Purpose: End-stage renal disease (ESRD) is an important complication arising after heart transplantation. At least 3-10% of recipients reach ESRD within 10 years after transplant. The incidence of ESRD in Chinese recipients has not been reported. Here we sought to assess the incidence, prognosis, and risk factors for ESRD in Chinese recipients. Methods: We conducted a retrospective analysis of 248 heart recipients who survived >1 year from 1998 through 2007. ESRD was defined as the requirement of maintenance dialysis. Results: Renal dysfunction was present in 20 patients (8%) prior to transplant. With a follow-up duration of 5.8±3.9 years, 30 patients developed ESRD. The cumulative incidence of ESRD after heart transplantation was 2.1%±0.9%, 6.5%±1.8%, 16.8%±3.3%, and 36.5%±9.5% at 2, 5, 10, and 15 years after transplant, respectively. Median onset of ESRD was 6.9 years after transplant. Actuarial survival after dialysis was 74.8%±8.3%, 66.6%±9.2%, and 43.6%±12.6% at 1, 2, and 5 years, respectively. Independent risk factors for ESRD included pretransplant serum creatinine (hazard ratio, 1.84; p=0.001), presence of diabetes prior to transplant (hazard ratio, 2.51; p=0.017), and old age at transplant (hazard ratio, 1.05; p=0.008). Conclusion: There was a high incidence of ESRD in Chinese heart recipients. Patients with ESRD had poor prognosis after dialysis.

KW - Asian Continental Ancestry Group

KW - Chronic

KW - Heart transplantation

KW - Kidney failure

UR - http://www.scopus.com/inward/record.url?scp=84892493552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892493552&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2012.04.012

DO - 10.1016/j.jfma.2012.04.012

M3 - Article

VL - 113

SP - 11

EP - 16

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 1

ER -