Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan

Hung Yi Chiou, Yu Mei Hsueh, Kuen Fu Liaw, Shan Far Horng, Ming Hsi Chiang, Yeong Shiau Pu, Johnny Shinn Nan Lin, Chun Hsiung Huang, Chien Jen Chen

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388 Citations (Scopus)

Abstract

In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with black-foot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years. The information on consumption of high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews. The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages. A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis. Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure.

Original languageEnglish
Pages (from-to)1296-1300
Number of pages5
JournalCancer Research
Volume55
Issue number6
Publication statusPublished - Mar 15 1995

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Arsenic
Taiwan
Incidence
Water Wells
Neoplasms
Urinary Bladder Neoplasms
Foot Diseases
Interviews
House Calls
Water
Certification
Feeding Behavior
Drinking
Registries
Life Style
Lung Neoplasms
Smoking
Regression Analysis
Health

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chiou, H. Y., Hsueh, Y. M., Liaw, K. F., Horng, S. F., Chiang, M. H., Pu, Y. S., ... Chen, C. J. (1995). Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan. Cancer Research, 55(6), 1296-1300.

Incidence of internal cancers and ingested inorganic arsenic : A seven-year follow-up study in Taiwan. / Chiou, Hung Yi; Hsueh, Yu Mei; Liaw, Kuen Fu; Horng, Shan Far; Chiang, Ming Hsi; Pu, Yeong Shiau; Lin, Johnny Shinn Nan; Huang, Chun Hsiung; Chen, Chien Jen.

In: Cancer Research, Vol. 55, No. 6, 15.03.1995, p. 1296-1300.

Research output: Contribution to journalArticle

Chiou, HY, Hsueh, YM, Liaw, KF, Horng, SF, Chiang, MH, Pu, YS, Lin, JSN, Huang, CH & Chen, CJ 1995, 'Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan', Cancer Research, vol. 55, no. 6, pp. 1296-1300.
Chiou, Hung Yi ; Hsueh, Yu Mei ; Liaw, Kuen Fu ; Horng, Shan Far ; Chiang, Ming Hsi ; Pu, Yeong Shiau ; Lin, Johnny Shinn Nan ; Huang, Chun Hsiung ; Chen, Chien Jen. / Incidence of internal cancers and ingested inorganic arsenic : A seven-year follow-up study in Taiwan. In: Cancer Research. 1995 ; Vol. 55, No. 6. pp. 1296-1300.
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