TY - JOUR
T1 - Incidence and risk factors of sudden cardiac death in bipolar disorder across the lifespan
AU - Chen, Pao Huan
AU - Tsai, Shang Ying
AU - Pan, Chun Hung
AU - Chang, Hu Ming
AU - Chen, Yi Lung
AU - Su, Sheng Siang
AU - Chen, Chiao Chicy
AU - Kuo, Chian Jue
N1 - Funding Information:
This research was supported by grants from the Ministry of Science and Technology, Taiwan (MOST 105-2314-B-532-006-MY3) and Taipei City Hospital (10501-62-015; TPECH 106-77). The funding sources had no involvement in the study design, data collection, analysis, interpretation of data, writing of the report, or the decision to submit the paper for publication.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Objective: Data on the incidence and risk factors of sudden cardiac death in patients with bipolar disorder are lacking in the literature. Methods: By using data from the Taiwan National Health Insurance Research Database and Department of Health Death Certification System between 2000 and 2016, we conducted a prospective national cohort study to determine the incidence and risk factors of sudden cardiac death in bipolar disorder patients. The study cohort included 46,490 patients with bipolar disorder, 467 of whom experienced sudden cardiac death. Results: Stratified analyses showed that the standardized mortality ratios (SMRs) of sudden cardiac death were all above 1.00 across each age interval, with the highest SMR in patients aged <30 years (31.96, 95% CI: 20.47–47.55). Notably, hypertension raised the risk of sudden cardiac death in both patients aged <50 years (1.85, 95% CI: 1.23–2.79) and aged ≥50 years (1.44, 95% CI: 1.14–1.83). In addition, venous and lymphatic disorders (1.97, 95% CI: 1.23–3.16), and alcohol use-related disorder (2.34, 95% CI: 1.62–3.38) elevated the risk of sudden cardiac death in patients aged <50 years. Congestive heart failure (1.59, 95% CI: 1.13–2.23) and dementia (1.75, 95% CI: 1.30–2.35) increased the risk of sudden cardiac death in patients aged ≥50 years. Conclusions: The risk of sudden cardiac death is remarkably high in bipolar disorder patients across the lifespan. Prevention strategies specific to individuals with bipolar disorder are urgently required.
AB - Objective: Data on the incidence and risk factors of sudden cardiac death in patients with bipolar disorder are lacking in the literature. Methods: By using data from the Taiwan National Health Insurance Research Database and Department of Health Death Certification System between 2000 and 2016, we conducted a prospective national cohort study to determine the incidence and risk factors of sudden cardiac death in bipolar disorder patients. The study cohort included 46,490 patients with bipolar disorder, 467 of whom experienced sudden cardiac death. Results: Stratified analyses showed that the standardized mortality ratios (SMRs) of sudden cardiac death were all above 1.00 across each age interval, with the highest SMR in patients aged <30 years (31.96, 95% CI: 20.47–47.55). Notably, hypertension raised the risk of sudden cardiac death in both patients aged <50 years (1.85, 95% CI: 1.23–2.79) and aged ≥50 years (1.44, 95% CI: 1.14–1.83). In addition, venous and lymphatic disorders (1.97, 95% CI: 1.23–3.16), and alcohol use-related disorder (2.34, 95% CI: 1.62–3.38) elevated the risk of sudden cardiac death in patients aged <50 years. Congestive heart failure (1.59, 95% CI: 1.13–2.23) and dementia (1.75, 95% CI: 1.30–2.35) increased the risk of sudden cardiac death in patients aged ≥50 years. Conclusions: The risk of sudden cardiac death is remarkably high in bipolar disorder patients across the lifespan. Prevention strategies specific to individuals with bipolar disorder are urgently required.
KW - Age effect
KW - Bipolar disorder
KW - Incidence
KW - Risk factor
KW - Standardized mortality ratio
KW - Sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=85085336036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085336036&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2020.05.094
DO - 10.1016/j.jad.2020.05.094
M3 - Article
C2 - 32469806
AN - SCOPUS:85085336036
VL - 274
SP - 210
EP - 217
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -